The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
Abstract
Background We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia.Methods Eight DSM-IV schizophrenia patients and 10 control subjects were studied with fMRI while they thought of the missing last word in 128 visually presented sentences. The fMRI data were analyzed comparing the effect of sentence completion (vs. rest) using a random effects analysis.Results There were no significant group differences in regional brain responses. Correlation coefficients between left temporal cortex (x = -54, y = -42, z = 3) and left dorsolateral prefrontal cortex (x = -39, y = 12, z = 24) were significantly lower in the schizophrenic group and were negatively correlated with the severity of auditory hallucinations.Conclusions Previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations.
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“Disrupted connectivity between frontal and temporal cortical areas has often been implicated in AVHs (Lawrie et al., 2002)”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Lawrie et al., 2002
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Metadata
- Authors
- Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., & Johnstone, E. C.
- Affiliations
- Royal Edinburgh Hospital (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 51
- Issue
- 12
- Pages
- 1008-1011
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2029059267
- Cited by
- 529
- References
- 15
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 9 · 2022: 16 · 2021: 20 · 2020: 14 · 2019: 16 · 2018: 24 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 27 · 2013: 41 · 2012: 33
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, auditory hallucinations, dorsolateral prefrontal cortex, left temporal cortex, hypofrontality, sentence completion task
- MeSH terms
- Adult, Female, Frontal Lobe, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Task Performance and Analysis, Temporal Lobe
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