The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Neocortical modulation of the amygdala response to fearful stimuli
Abstract
Background The cortical circuitry involved in conscious cognitive processes and the subcortical circuitry involved in fear responses have been extensively studied with neuroimaging, but their interactions remain largely unexplored. A recent functional magnetic resonance imaging (fMRI) study demonstrated that the engagement of the right prefrontal cortex during the cognitive evaluation of angry and fearful facial expressions is associated with an attenuation of the response of the amygdala to these same stimuli, providing evidence for a functional neural network for emotional regulation.Methods In the current study, we have explored the generalizability of this functional network by using threatening and fearful non-face stimuli derived from the International Affective Picture System (IAPS), as well as the influence of this network on peripheral autonomic responses.Results Similar to the earlier findings with facial expressions, blood oxygen level dependent fMRI revealed that whereas perceptual processing of IAPS stimuli was associated with a bilateral amygdala response, cognitive evaluation of these same stimuli was associated with attenuation of this amygdala response and a correlated increase in response of the right prefrontal cortex and the anterior cingulate cortex. Moreover, this pattern was reflected in changes in skin conductance.Conclusions The current results further implicate the importance of neocortical regions, including the prefrontal and anterior cingulate cortices, in regulating emotional responses mediated by the amygdala through conscious evaluation and appraisal.
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“previous findings showing that the ACC has a crucial role within a general neural fear circuit (Hariri et al, 2003) as well as within the framework of Pavlovian fear conditioning (see reviews by Milad et al, 2007;Sehlmeyer et al, 2009).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Hariri et al, 2003
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(2001) · doi:10.1017/cbo9780511546396 · Cited by 4,482
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
International Affective Picture System (IAPS) : Technical Manual and Affective Ratings
Lang, P. J. (1995) · Medical Entomology and Zoology · Cited by 2,870
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001
Dawson, M. E., Schell, A. M., Filion, D. L., & Berntson, G. G. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546396.007 · Cited by 1,776
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722 · cited 2×
“behavioral responses (Paus 2001).”
MethodRight hemispheric dominance of inhibitory control: An event-related functional MRI study
Garavan, H., Ross, T. J., & Stein, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8301 · Cited by 1,394
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OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
Social Cognitive Neuroscience: A Review of Core Processes
Lieberman, M. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085654 · Cited by 2,010
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Optimizing inhibitory learning during exposure therapy
Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607
Toward a unified treatment for emotional disorders
Barlow, D. H., Allen, L. B., & Choate, M. L. (2004) · Behavior Therapy · doi:10.1016/s0005-7894(04)80036-4 · Cited by 1,430
Metadata
- Authors
- Hariri, A. R., Mattay, V. S., Tessitore, A., Fera, F., & Weinberger, D. R.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Hariri, Ahmad R
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 53
- Issue
- 6
- Pages
- 494-501
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2016660677
- Cited by
- 828
- References
- 40
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 24 · 2021: 27 · 2020: 30 · 2019: 23 · 2018: 38 · 2017: 28 · 2016: 35 · 2015: 51 · 2014: 37 · 2013: 50 · 2012: 52
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- amygdala, fear, emotion regulation, prefrontal cortex, anterior cingulate cortex, threat appraisal, skin conductance, autonomic responses, International Affective Picture System, facial expressions
- MeSH terms
- Adult, Affect, Amygdala, Cognition, Equipment Design, Fear, Female, Galvanic Skin Response, Humans, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Prefrontal Cortex
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