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The genetics of pediatric-onset bipolar disorder
Abstract
Although bipolar disorder in adults has been extensively studied, early-onset forms of the disorder have received less attention. We review several lines of evidence indicating that pediatric- and early adolescent-onset bipolar disorder cases may prove the most useful for identifying susceptibility genes. Family studies have consistently found a higher rate of bipolar disorder among the relatives of early-onset bipolar disorder patients than in relatives of later-onset cases, which supports the notion of a larger genetic contribution to the early-onset cases. Comorbid pediatric bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) may also define a familial subtype of ADHD or bipolar disorder that is strongly influenced by genetic factors and may, therefore, be useful in molecular genetic studies. There are no twin and adoption studies of pediatric bipolar disorder, but the heritability of this subtype is expected to be high given the results from family studies. Thus, pediatric- and early adolescent-onset bipolar disorder may represent a genetically loaded and homogeneous subtype of bipolar disorder, which, if used in genetic linkage and association studies, should increase power to detect risk loci and alleles.
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“There is evidence to suggest that bipolar disorder consists of multiple distinct subtypes.”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Faraone et al., 2003
In the citing paper
“One measure that appears to stratify some of these subtypes is age at onset (Faraone et al., 2003; Potash et al., 2007).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Faraone et al., 2003
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Metadata
- Authors
- Faraone, S. V., Glatt, S. J., & Tsuang, M. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Faraone, Stephen V
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 53
- Issue
- 11
- Pages
- 970-977
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2056424385
- Cited by
- 151
- References
- 81
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 13
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH 60485, R01MH059624, R01MH43518, R25 MH60485, R01MH057934, R01MH043518, R25MH060485, R13 MH59126, R01 MH 59624, R01MH-57934, R13MH059126)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD37694, R01HD037694)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- early-onset bipolar disorder, susceptibility genes, family studies, heritability, ADHD comorbidity, genetic linkage, genetic association, genetic susceptibility loci
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Child, Child Behavior Disorders, Child, Preschool, Family, Humans, Molecular Biology, Comorbidity, Age of Onset, Age Distribution, Twin Studies as Topic, Genetic Predisposition to Disease
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