Cited by 362Musculoskeletal pain and rehabilitationPsychosomatic Disorders and Their TreatmentsPain Mechanisms and Treatments

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Persistent pain and depression: a biopsychosocial perspective

Campbell, Lisa C, Clauw, Daniel J, Keefe, Francis J·2003·Biological Psychiatry

DOI 10.1016/s0006-3223(03)00545-6

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Abstract

This review highlights recent research findings on the relationship between persistent pain and depression and discusses the implications of these findings for future research in persons who suffer from both pain and depression. First, we briefly discuss advances in theories of pain that underscore the important role that depression can play in the chronic pain experience. Second, we discuss depression in persons suffering from chronic pain from a biopsychosocial perspective that takes into account both biological and psychosocial mechanisms linking pain and depression. Third, we address biomedical, psychosocial, and combined medical-psychosocial approaches to treatment in persons with persistent pain and depression. We conclude by highlighting future directions for research related to screening and diagnosis of depression in persons having persistent pain, treatment of comorbid pain and depression, and individual and subgroup differences in the experience of persistent pain and depression.

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Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926
Cognitive Therapy in Depression
Kovács, M. (1980) · Journal of the American Academy of Psychoanalysis · doi:10.1521/jaap.1.1980.8.1.127 · Cited by 3,422
Pain mechanisms: A new theory
Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Handbook of pain assessment
Benjamin, S. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90012-4 · Cited by 2,001
Behavioral methods for chronic pain and illness
Fordyce, W. E. (1977) · Pain · doi:10.1016/0304-3959(77)90029-x · Cited by 1,630
Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache
Morley, S., Eccleston, C., & Williams, A. (1999) · Pain · doi:10.1016/s0304-3959(98)00255-3 · Cited by 1,597
Handbook of pain assessment
Williams, A. C. D. C. (1995) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(95)90016-0 · Cited by 1,472

Show all 116 references

Research works printed but not linked: 2

Covic, 2002, The role of passive coping and helplessness in rheumatoid arthritis depression and pain, J App Health Beh, 4, 31
Delgado, 2000, Depression, J Clin Psychiatry, 61, 7

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Berquin, A., & Grisart, J. (2016) · Les défis de la douleur chronique · doi:10.3917/mard.berq.2016.01.0515
Psychische Störungen in der inneren Medizin und Chirurgie
(2009) · Springer eBooks · doi:10.1007/978-3-540-27243-4_13
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Bibliography: Geriatric Psychiatry
(2009) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.7.1.foc46
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Pereira, E. D. S. B. M., Rocha, A. L. D. S., de Castro, M. V. M., Eleutério, R. G., Pomini, K. T., Guiguer, É. L., & Chagas, E. F. B. (2023) · Peer Review · doi:10.53660/868.prw2502
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The Psychology of Pelvic Pain
Alamgir, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-12105-0.00004-5
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Fu, S., Zhang, Y., Wang, K., Lei, W., Liu, Q., Tian, J., Li, B., Yun, T., Zhao, Y., Lin, J., et al. (2025) · Depression and Anxiety · doi:10.1155/da/5565953
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Luo, A., Wu, Z., Li, S., McReynolds, C. B., Wang, D., Liu, H., Huang, C., He, T., Zhang, X., Wang, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26565824
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Huang, J., Xu, S., Li, H., Xia, W., Liu, C., & Liu, H. (2026) · BMC Public Health · doi:10.1186/s12889-026-26750-5
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Gregoor, M., Peuskens, E., Geerits, E., Aldabe, D., Geraerts, I., Baets, L. D., Bogaerts, A., GYSELAERS, W., Goossens, N., & Janssens, L. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-09029-w
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She, R., Luo, H., Chen, S., Xiong, F., Liu, K. P. Y., & Pang, M. Y. C. (2026) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796026100626
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Kumaradev, S. (2023) · theses.fr (ABES) · doi:10.70675/b230e3afz9749z4ab5zb9a9zbbc06bdf1d6d
The longitudinal relationship between pain and depressive symptoms in later life: the buffering effects of social and physical activities among older Koreans
Song, E., & Kim, J. (2026) · Innovation in Aging · doi:10.1093/geroni/igag037
Therapeutic potential of CMPP, a novel maleimide derivative, in a reserpine-induced mouse model of pain–depression dyad
Alzoubi, L., Bseiso, Y., Gammoh, O., Aljabali, A. A. A., Salameh, B. A. B., Alqudah, A. M., Qnais, E., Al-malkawi, A. M., & Safieh, K. A. A. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102675
An Analytical Study on the Identification of Factors That May Cause Depression in Patients Receiving Chronic Pain Treatment
Karadavut, U., & Urmonjonovich, T. G. (2025) · International Journal of Computational and Experimental Science and Engineering · doi:10.22399/ijcesen.5068
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Mauricenz, A. P., & Carrias, M. C. (2026) · Psicologia e Saúde em Debate · doi:10.22289/2446-922x.v12a1a92
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Tomlinson, P. L., Sauers, K. N., Nosal, E., Davies, B., McGarvey, C. E., & Stackhouse, J. (2026) · Cureus · doi:10.7759/cureus.117097
Individualized machine-learning predictions of pain intensity in chronic low back pain
Herbert, M. S., Nan, J., Fishbein, J. N., Bulls, H. W., Bustamante, S., Fikingas, S., Wang, Y., Ramanathan, D., & Mishra, J. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106456
Cingulate thrombospondin 4 protects against neuropathic pain and comorbid anxiodepression via interaction with EAAT2
Liu, W., Han, W., Dou, Z., Liu, K., Zhao, R., Xie, R., Wu, S.-X., Li, Z.-Z., & Luo, C. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118112
Mood disorders
Anderson, E. L. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139021319.009
Effective Psychological Evaluation and Management of Behavioral Health Concerns
Warren, P. A. (2010) · Springer eBooks · doi:10.1007/978-0-387-09814-2_3
Central and peripheral mechanisms of pain in clinical knee osteoarthritis
Mason, K. J. (2015) · Research Explorer (The University of Manchester)
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Warren, P. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89860-5_1
Untitled work
(2009) · PubMed · Cited by 19

Authors: Campbell, L. C., Clauw, D. J., & Keefe, F. J.
Affiliations: Duke University (US)
Corresponding author: Keefe, Francis J
ORCID: Campbell, Lisa C
Clauw, Daniel J
Keefe, Francis J
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2003-08
Volume: 54
Issue: 3
Pages: 399-409
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(03)00545-6
OpenAlex: W1992795892
Cited by: 362
References: 116
Citations by year: 2026: 10 · 2025: 16 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 19 · 2016: 12 · 2015: 28 · 2014: 30 · 2013: 24 · 2012: 17
FWCI: 1.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (63429)
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: chronic pain, depression, biopsychosocial model, pain theories, pain-depression comorbidity, psychosocial mechanisms, biological mechanisms, pain management, subgroup differences
MeSH terms: Depression, Depressive Disorder, Humans, Pain, Pain Management

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Persistent pain and depression: a biopsychosocial perspective

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