The DOI matches its Crossref record; 113 of the 116 references it cites were found in a registry or an index.
Persistent pain and depression: a biopsychosocial perspective
Abstract
This review highlights recent research findings on the relationship between persistent pain and depression and discusses the implications of these findings for future research in persons who suffer from both pain and depression. First, we briefly discuss advances in theories of pain that underscore the important role that depression can play in the chronic pain experience. Second, we discuss depression in persons suffering from chronic pain from a biopsychosocial perspective that takes into account both biological and psychosocial mechanisms linking pain and depression. Third, we address biomedical, psychosocial, and combined medical-psychosocial approaches to treatment in persons with persistent pain and depression. We conclude by highlighting future directions for research related to screening and diagnosis of depression in persons having persistent pain, treatment of comorbid pain and depression, and individual and subgroup differences in the experience of persistent pain and depression.
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“In the general population, depression is associated with a wide range of health, mental health, and neurological conditions, such as 1) chronic pain [71–75]; 2) headaches and migraines [76–79]; 3) diabetes [80–82]; 4) low testosterone [83–85]; 5) cardiovascular, cerebrovascular, and small vessel ischemic disease [86–92]; 6) PD [93]; 7) MCI [94–96]; and 8) AD [97].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [74]
Citations
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The effect of pain on cognitive function: A review of clinical and preclinical research
Moriarty, O., McGuire, B. E., & Finn, D. P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.002 · Cited by 1,122
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
Recurrent Concussion and Risk of Depression in Retired Professional Football Players
GUSKIEWICZ, K. M., MARSHALL, S. W., BAILES, J., MCCREA, M., HARDING, H. P., MATTHEWS, A., MIHALIK, J. R., & CANTU, R. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180383da5 · Cited by 928
An Interdisciplinary Expert Consensus Statement on Assessment of Pain in Older Persons
Hadjistavropoulos, T., Herr, K., Turk, D. C., Fine, P. G., Dworkin, R. H., Helme, R. D., Jackson, K. C., Parmelee, P. A., Rudy, T. E., Beattie, B. L., et al. (2006) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31802be869 · Cited by 570
Family-centered Preparation for Surgery Improves Perioperative Outcomes in Children
Kain, Z. N., Caldwell-Andrews, A. A., Mayes, L. C., Weinberg, M. E., Wang, S., MacLaren, J. E., & Blount, R. L. (2007) · Anesthesiology · doi:10.1097/00000542-200701000-00013 · Cited by 430
Metadata
- Authors
- Campbell, L. C., Clauw, D. J., & Keefe, F. J.
- Affiliations
- Duke University (US)
- Corresponding author
- Keefe, Francis J
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 54
- Issue
- 3
- Pages
- 399-409
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1992795892
- Cited by
- 362
- References
- 116
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 19 · 2016: 12 · 2015: 28 · 2014: 30 · 2013: 24 · 2012: 17
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (63429)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- chronic pain, depression, biopsychosocial model, pain theories, pain-depression comorbidity, psychosocial mechanisms, biological mechanisms, pain management, subgroup differences
- MeSH terms
- Depression, Depressive Disorder, Humans, Pain, Pain Management
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