The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Depression and cancer: mechanisms and disease progression
Abstract
Depression and cancer commonly co-occur. The prevalence of depression among cancer patients increases with disease severity and symptoms such as pain and fatigue. The literature on depression as a predictor of cancer incidence is mixed, although chronic and severe depression may be associated with elevated cancer risk. There is divided but stronger evidence that depression predicts cancer progression and mortality, although disentangling the deleterious effects of disease progression on mood complicates this research, as does the fact that some symptoms of cancer and its treatment mimic depression. There is evidence that providing psychosocial support reduces depression, anxiety, and pain, and may increase survival time with cancer, although studies in this latter area are also divided. Psychophysiological mechanisms linking depression and cancer progression include dysregulation of the hypothalamic-pituitary-adrenal axis, especially diurnal variation in cortisol and melatonin. Depression also affects components of immune function that may affect cancer surveillance. Thus, there is evidence of a bidirectional relationship between cancer and depression, offering new opportunities for therapeutic intervention.
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“A 2003 article by Spiegel and Giese-Davis pointed out that depression may predict cancer’s progression and mortality through a bidirectional relationship between depression and cancer; depression and cancer can negatively affect each other [7].”
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Cites
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Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
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“Clinical depression may have stronger effects on mortality because depressive symptoms in the lower range may be less likely to affect the suggested moderators of the depression–mortality relationship, such as low compliance (Spiegel & Giese-Davis, 2003).”
BackgroundInfluentialAdvances and Open Questions in the Science of Subjective Well-Being
Diener, E., Lucas, R. E., & Oishi, S. (2018) · Collabra Psychology · doi:10.1525/collabra.115 · Cited by 1,333
Metadata
- Authors
- Spiegel, D., & Giese-Davis, J.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Spiegel, David
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 54
- Issue
- 3
- Pages
- 269-282
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2032018235
- Cited by
- 874
- References
- 147
- Citations by year
- 2026: 27 · 2025: 36 · 2024: 36 · 2023: 35 · 2022: 42 · 2021: 42 · 2020: 55 · 2019: 43 · 2018: 44 · 2017: 28 · 2016: 37 · 2015: 42 · 2014: 36 · 2013: 40 · 2012: 58
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- National Institutes of Health (5R01 MH047226)
- National Institute of Mental Health (5P01AG018784)
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, cancer, tumor progression, cancer mortality, cancer incidence, psychosocial support, hypothalamic-pituitary-adrenal axis, cortisol, melatonin, immune function, cancer surveillance, pain, fatigue, bidirectional relationship
- MeSH terms
- Adrenal Glands, Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Neoplasms, Risk Factors, Treatment Refusal, Disease Progression
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