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Cited by 874Cancer, Stress, Anesthesia, and Immune ResponseCancer survivorship and careTryptophan and brain disorders

The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.

Depression and cancer: mechanisms and disease progression

Spiegel, David, Giese-Davis, Janine·2003·Biological Psychiatry
DOI 10.1016/s0006-3223(03)00566-3
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Abstract

Depression and cancer commonly co-occur. The prevalence of depression among cancer patients increases with disease severity and symptoms such as pain and fatigue. The literature on depression as a predictor of cancer incidence is mixed, although chronic and severe depression may be associated with elevated cancer risk. There is divided but stronger evidence that depression predicts cancer progression and mortality, although disentangling the deleterious effects of disease progression on mood complicates this research, as does the fact that some symptoms of cancer and its treatment mimic depression. There is evidence that providing psychosocial support reduces depression, anxiety, and pain, and may increase survival time with cancer, although studies in this latter area are also divided. Psychophysiological mechanisms linking depression and cancer progression include dysregulation of the hypothalamic-pituitary-adrenal axis, especially diurnal variation in cortisol and melatonin. Depression also affects components of immune function that may affect cancer surveillance. Thus, there is evidence of a bidirectional relationship between cancer and depression, offering new opportunities for therapeutic intervention.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(03)00566-3

Cites

149 of 149 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 6

  1. Ilnyckyj, 1994, A randomized controlled trial of psychotherapeutic intervention in cancer patients, Ann R Coll Physicians Surg Can, 27, 93
  2. Kuchler, 1999, Impact of psychotherapeutic support on gastrointestinal cancer patients undergoing surgery, Hepatogastroenterology, 46, 322
  3. Landmann, 1984, Changes of immunoregulatory cells induced by psychological and physical stress, Clin Exp Immunol, 58, 127
  4. Lerman, 1994, Younger women at increased risk for breast cancer, J Natl Cancer Inst Monogr, 16, 171
  5. Mormont, 2002, Cortisol diurnal variation in blood and saliva of patients with metastatic colorectal cancer, Anticancer Res, 22, 1243
  6. Wellisch, 1991, Psychosocial outcomes of breast cancer therapies, Psychosomatics, 32, 177

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Metadata

Authors
Spiegel, D., & Giese-Davis, J.
Affiliations
Stanford Medicine (US)
ORCID
Spiegel, David
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-08
Volume
54
Issue
3
Pages
269-282
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(03)00566-3
OpenAlex
W2032018235
Cited by
874
References
147
Citations by year
2026: 27 · 2025: 36 · 2024: 36 · 2023: 35 · 2022: 42 · 2021: 42 · 2020: 55 · 2019: 43 · 2018: 44 · 2017: 28 · 2016: 37 · 2015: 42 · 2014: 36 · 2013: 40 · 2012: 58
FWCI
3.61
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute
  • National Institutes of Health (5R01 MH047226)
  • National Institute of Mental Health (5P01AG018784)
  • National Institute on Aging
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
depression, cancer, tumor progression, cancer mortality, cancer incidence, psychosocial support, hypothalamic-pituitary-adrenal axis, cortisol, melatonin, immune function, cancer surveillance, pain, fatigue, bidirectional relationship
MeSH terms
Adrenal Glands, Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Neoplasms, Risk Factors, Treatment Refusal, Disease Progression

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