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Plasma levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers
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Prior work indicates its active metabolite may have different effects on alertness compared to trazodone itself.
“given that prior work indicates its active metabolite may have different effects on alertness compared to trazodone itself [38]”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [38]
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Cites
No references could be resolved yet.
Research works printed but not linked: 6
- Baran, 1979, On the central antiserotonin action of trazodone, Pol J Pharmacol, 31, 25
- Benjamin J, Greenberg J, Murphy DL (in press): Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects. Psychopharmacology. · DOI
- Lawlor, 1991, Effects of nighttime administration of the serotonin agonist, m-CPP on sleep architecture and behavior in healthy volunteers, Biol Psychiatry, 29, 281, 10.1016/0006-3223(91)91290-8 · DOI · Paper page
- Maj, 1979, Trazodone, a central serotonin antagonist and agonist, J Neural Transm Gen Sect, 44, 237, 10.1007/BF01253065 · DOI
- Murphy, 1989, Comparative anxiogenic, neuroendocrine and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers, Psychopharmacology, 98, 275, 10.1007/BF00444705 · DOI
- Sansone, 1983, Reversal of depressant action of trazodone on avoidance behavior by its metabolite m-chlorophenylpiperazine, J Pharm Pharmacol, 35, 189, 10.1111/j.2042-7158.1983.tb04307.x · DOI
Cited by
Sorted by citations
Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers
La, A. L., Walsh, C. M., Neylan, T. C., Vossel, K. A., Yaffe, K., Krystal, A. D., Miller, B. L., & Karageorgiou, E. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181145 · Cited by 83
Metadata
- Authors
- Lawlor, B. A., Radcliffe, J., Martinez, R., Sunderland, T., & Murphy, D. L.
- Affiliations
- St. James's Hospital (IE)
- National Institute of Mental Health (US)
- Corresponding author
- Lawlor, Brian A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 41
- Issue
- 6
- Pages
- 756-757
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2095266988
- Cited by
- 9
- References
- 0
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2013: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- m-chlorophenylpiperazine, trazodone, plasma drug concentration, single oral dose, drug interactions, phenothiazines, antidepressants, pharmacokinetics
- MeSH terms
- Chromatography, High Pressure Liquid, Double-Blind Method, Drug Interactions, Female, Humans, Male, Middle Aged, Piperazines, Trazodone, Serotonin Receptor Agonists, Cross-Over Studies, Antidepressive Agents, Second-Generation
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