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Cited by 51Sleep and related disordersSleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

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A preliminary study of the effects of nighttime administration of the serotonin agonist, m-CPP, on sleep architecture and behavior in healthy volunteers

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Lawlor, Brian A., Newhouse, Paul A., Balkin, Thomas J., Molchan, Susan E., Mellow, Alan M., Murphy, Dennis L., Sunderland, Trey·1991·Biological Psychiatry
DOI 10.1016/0006-3223(91)91290-8
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Abstract

The effects of m-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) on sleep architecture and behavior were examined in six healthy volunteers following a single oral dose of the drug in a randomized, double-blind, placebo-controlled study. m-CPP reduced total sleep time (TST) and sleep efficiency in all subjects. Slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep were decreased and stage 1 sleep was prolonged in a majority of subjects. Prominent behavioral and psychological effects were reported in five out of six subjects following m-CPP (but not following placebo) that interfered with sleep. The sleep disruption and behavioral activation following nighttime administration of m-CPP contrasts with the sedative properties of its parent compound, trazodone, suggesting that the hypnotic effect of trazodone is not related to the agonist profile of its metabolite, m-CPP.

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  • Sleep fragmentation is more likely to be due to stimulation of 5-HT2 receptors.

    “This is more likely to be due to stimulation of 5-HT2 receptors (Lawlor et al., 1991).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Lawlor et al., 1991

    The Discussion reports disrupted sleep after m-CPP and suggests that its 5-HT agonist activity could explain the changes. But the Introduction says m-CPP binds to several receptor subtypes and that its exact receptor site of action in humans is uncertain; the paper does not identify 5-HT2 stimulation specifically as the more likely cause of sleep fragmentation. (LLM, conf=0.86)

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Research works printed but not linked: 25

  1. Aloi, 1984, Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys, Life Sci, 34, 1325, 10.1016/0024-3205(84)90003-1 · DOI
  2. Aulakh, 1987, Long-term imipramine treatment enhances locomotor and food intake suppressant effects of m-chlorophenylpiperazine in rats, Br J Pharmacol, 91, 747, 10.1111/j.1476-5381.1987.tb11272.x · DOI
  3. Charney, 1987, Serotonin function in anxiety. II. Effects of the serotonin agonist m-CPP in panic disorder patients and healthy subjects, Psychopharmacology, 92, 14, 10.1007/BF00215473 · DOI
  4. Dugovic, 1987, 5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat, Eur J Pharmacol, 137, 145, 10.1016/0014-2999(87)90196-8 · DOI
  5. Fornal, 1983, Sleep suppressant action of fenfluramine in rats. I. Relation to postsynaptic serotonergic stimulation, J Pharmacol Exp Ther, 225, 667
  6. Fristal, 1989, Lithium increases slow wave sleep: Possible mediation by brain 5-HT2 receptors, Psychopharmacology, 98, 139, 10.1007/BF00442020 · DOI
  7. Hamik, 1989, 1-(m-Chlorophenyl)piperazine (m-CPP) interactions with neurotransmitter receptors in the human brain, Biol Psychiatry, 25, 569, 10.1016/0006-3223(89)90217-5 · DOI
  8. Heuring, 1986, Species variations in RU 24969 interactions wit non 5-HT1A binding sites, Eur J Pharmacol, 122, 279, 10.1016/0014-2999(86)90114-7 · DOI
  9. Hoyer, 1986, Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites, Brian Res, 376, 85, 10.1016/0006-8993(86)90902-9 · DOI
  10. Idzikowski, 1986, 5-Hydroxytryptamine-2-antagonist increases human slow wave sleep, Brain Res, 378, 164, 10.1016/0006-8993(86)90299-4 · DOI
  11. Idzikowski, 1987, The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan, Psychopharmacology, 93, 416, 10.1007/BF00207228 · DOI
  12. Kennett, 1988, Evidence that m-CPP may have behavioral effects mediated by central 5-HT1C receptors, Br J Pharmacol, 94, 137, 10.1111/j.1476-5381.1988.tb11508.x · DOI
  13. Kovacevic, 1976, Monoamine changes in the brain of cats during slow wave sleep, Science, 193, 1025, 10.1126/science.948760 · DOI
  14. Kupfer, 1974, Lithium Carbonate and sleep in affective disorders: Further considerations, Arch Gen Psychiatry, 30, 79, 10.1001/archpsyc.1974.01760070061009 · DOI
  15. Lawlor, 1989, Hyperresponsivity to the serotonin agonist, m-chlorophenylpiperazine in Alzheimer's disease: A controlled study, Arch Gen Psychiatry, 46, 542, 10.1001/archpsyc.1989.01810060064010 · DOI
  16. Maj, 1979, Trazodone, a central antagonist and agonist, J Neural Transm, 44, 237, 10.1007/BF01253065 · DOI
  17. Montgomery, 1983, Trazodone enhances sleep in subjective quality but not in objective duration, Br J Clin Pharmacol, 16, 139, 10.1111/j.1365-2125.1983.tb04977.x · DOI · Paper page
  18. Mouret, 1988, Effects of trazodone on the sleep of depressed subjects: A polygraphic study, Psychopharmacology, 95, S37, 10.1007/BF00172629 · DOI · Paper page
  19. Mueller, 1985, Neuroendocrine effects of m-chlorophenylpiperazine, a serotonin agonist, in humans, J Clin Endocrinol Metab, 61, 1179, 10.1210/jcem-61-6-1179 · DOI
  20. Mueller, 1986, Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: Evidence for a serotonin receptor mediated mechanism of action in humans, Psychopharmacology, 89, 388, 10.1007/BF00174380 · DOI
  21. Murphy, 1989, Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers, Psychopharmacology, 98, 275, 10.1007/BF00444705 · DOI
  22. Nicholson, 1986, 5-Hydroxytryptamine and noradrenaline uptake inhibition : Studies on sleep in man, Neuropharmacology, 25, 1079, 10.1016/0028-3908(86)90153-X · DOI
  23. Rokosz-Pelc, 1980, 5-Hydroxytryptamine-like properties of m-chlorophenylpiperazine: Comparison with quipazine, J Pharm Pharmacol, 32, 220, 10.1111/j.2042-7158.1980.tb12896.x · DOI
  24. Seidel, 1985, Buspirone, an anxiolytic without sedative properties, Psychopharmacology, 87, 371, 10.1007/BF00432724 · DOI
  25. Sills, 1984, Determination of selective and nonselective compounds for the 5-HT1A and 5-HT1B receptor subtypes in rat frontal cortex, J Pharmacol Exp Ther, 231, 480

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Metadata

Authors
Lawlor, B. A., Newhouse, P. A., Balkin, T. J., Molchan, S. E., Mellow, A. M., Murphy, D. L., & Sunderland, T.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Vermont (US)
  • Walter Reed Army Institute of Research (US)
  • National Institute of Mental Health (US)
  • University of Michigan (US)
Corresponding author
Lawlor, Brian A.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1991-02
Volume
29
Issue
3
Pages
281-286
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(91)91290-8
OpenAlex
W2132256993
Cited by
51
References
0
Citations by year
2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2013: 2
FWCI
6.29
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
m-chlorophenylpiperazine, serotonin receptor agonists, sleep architecture, sleep disruption, total sleep time, slow-wave sleep, REM sleep, stage 1 sleep, sleep efficiency, behavioral activation, trazodone, hypnotic effects
MeSH terms
Administration, Oral, Adult, Aged, Arousal, Circadian Rhythm, Electroencephalography, Female, Humans, Male, Middle Aged, Piperazines, Receptors, Serotonin, Sleep Stages, Sleep, REM

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