Antidepressantlike effects of chronic nicotine on learned helplessness paradigm in rats
Abstract
Background The association between smoking and depression has been widely investigated. Smoking cessation is known to induce depression to a variable extent, and patients with a history of depression are more likely to experience depressive symptoms. To investigate the hypothesis that nicotine may have an antidepressantlike effect, we used learned helpless rats as an animal model of depression.Methods Learned helplessness was produced according to our previous method. Learned helpless rats were implanted with nicotine and escape test was performed at 7 and 14 days after the implantation.Results The number of escape failure in the rats receiving 1.5 mg/kg/day of nicotine was significantly reduced (p < .05) compared to control at day 14. Furthermore, this effect was blocked when the nicotinic receptor antagonist mecamylamine was coadministered.Conclusions These results suggest that chronic nicotine may act as an antidepressant, probably via nicotinic receptors.
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Chronic nicotine administration can elicit antidepressant-like effects in rats in the learned helplessness and forced swim paradigms.
“Animal studies have also shown that chronic nicotine administration can elicit antidepressant-like effects in rats both in the learned helplessness (Semba et al., 1998) and the forced swim (Djuric et al., 1999; Tizabi et al., 1999) paradigms.”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Semba et al., 1998
The agonist nicotine and the antagonist mecamylamine both exert antidepressant-like effects.
“Behavioral studies also show that the agonist nicotine and the antagonist mecamylamine both improve memory-related task performance in rodents and monkeys (Buccafusco and Jackson, 1991;Terry et al., 1999) and exert antidepressant-like effects (Semba et al., 1998;Tizabi et al., 1998;Shytle et al., 2002;Gatto et al., 2004).”
From Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization (2010) · cites this paper as Semba et al., 1998
Nicotine had an antidepressant effect in the forced swim test, the chronic mild stress sucrose test, and learned helplessness.
“nicotine had an antidepressant effect in the forced swim test (Andreasen & Redrobe, 2009; Suemaru et al., 2006; Tizabi, Getachew, Rezvani, Hauser, & Overstreet, 2009, Tizabi et al., 1999; Vázquez-Palacios, Bonilla-Jaime, & Velázquez-Moctezuma, 2005), the chronic mild stress sucrose test (Andreasen, Henningsen, Bate, Christiansen, & Wiborg, 2011), and learned helplessness (Semba, Mataki, Yamada, N”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Semba et al., 1998
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References 21 · Cited by 140
- Authors
- Semba, J., Mataki, C., Yamada, S., Nankai, M., & Toru, M.
- Affiliations
- The Open University of Japan (JP)
- Toho University (JP)
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Semba, Jun’ichi
- ORCID
- Yamada, Satoru
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 43
- Issue
- 5
- Pages
- 389-391
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2032654738
- Cited by
- 140
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- nicotine, antidepressant effects, learned helplessness, depression, nicotinic acetylcholine receptors, mecamylamine, smoking cessation, escape behavior, rats
- MeSH terms
- Animals, Antidepressive Agents, Behavior, Animal, Escape Reaction, Helplessness, Learned, Male, Mecamylamine, Nicotine, Rats, Wistar, Nicotinic Agonists, Nicotinic Antagonists, Rats
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