A rapid-cycling bipolar patient treated with long nights, bedrest, and light
Abstract
Background Stabilization of rapid-cycling bipolar disorder is extremely difficult. Methods A refractory bipolar I rapid-cycling patient on valproate was treated with long "nights" (extended sleep in darkness) and daytime light therapy. Results Rapid cycling immediately stopped on initiation of a 10 hour dark/rest period. This was extended to 14 hours (plus a self-selected 1 hour midday nap) without problems. Depression gradually improved when midday light therapy was added; near-euthymia was attained after light therapy was shifted to the morning. Conclusions Nonpharmacological chronobiological treatments may be a means to interrupt rapid cycling.
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A refractory bipolar I rapid-cycling patient who failed treatment with only a mood stabilizer improved with the addition of a combination of dark therapy and daytime light therapy.
“Wirz‐Justice and colleagues reported an interesting case on a refractory bipolar I rapid‐cycling patient, who failed to be treated with only a mood stabilizer, and yet improved by the addition of a combination of dark therapy and daytime light therapy (Wirz‐Justice et al., 1999).”
From Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta‐analysis of randomized controlled trials (2020) · cites this paper as Wirz‐Justice et al., 1999
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- Authors
- Wirz-Justice, A., Quinto, C., Cajochen, C., Werth, E., & Hock, C.
- Affiliations
- Universitäre Psychiatrische Kliniken Basel (CH)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 45
- Issue
- 8
- Pages
- 1075-1077
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2012409636
- Cited by
- 87
- References
- 1
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- rapid cycling bipolar disorder, bipolar I disorder, phototherapy, non-pharmacological treatment, valproic acid, depression, sleep deprivation, circadian rhythm
- MeSH terms
- Activity Cycles, Aged, Bed Rest, Bipolar Disorder, Chronobiology Phenomena, Circadian Rhythm, Female, Humans, Phototherapy, Time Factors
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