Chronotherapeutics (light and wake therapy) in affective disorders
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The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic subtype, respond with marked improvement within hours. Treatment can be a single or repeated sleep deprivation, total (all night) or partial (second half of the night). Relapse can be prevented by daily light therapy, concomitant administration of SSRIs, lithium (for bipolar patients), or a short phase advance of sleep over 3 days following a single night of wake therapy. Combinations of these interventions show great promise. (2) Light therapy is effective for major depression--not only for the seasonal subtype. As an adjuvant to conventional antidepressants in unipolar patients, or lithium in bipolar patients, morning light hastens and potentiates the antidepressant response. Light therapy shows benefit even for patients with chronic depression of 2 years or more, outperforming their weak response to drugs. This method provides a viable alternative for patients who refuse, resist or cannot tolerate medication, or for whom drugs may be contraindicated, as in antepartum depression. (3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority.
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Follow-up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can prevent relapse after total sleep deprivation.
“Furthermore, follow up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can also prevent relapse (Berger et al., 1997; Riemann et al., 1999; Wirz-Justice et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Wirz-Justice et al., 2005
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Golden, R. N., Gaynes, B. N., Ekstrom, R. D., Hamer, R. M., Jacobsen, F. M., Suppes, T., Wisner, K. L., & Nemeroff, C. B. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.656 · Cited by 896 · cited 2× · see citing works
“Building on the example of the American Psychiatric Association ( Golden et al. in press ), national psychiatric associations should exert clinical leadership and develop standards of practice for chronotherapeutics.”
BackgroundMethodWu, J. C., & Bunney, W. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.1.14 · Cited by 614 · see citing works
Self-citationSmeraldi, E., Zanardi, R., Benedetti, F., Bella, D. D., Pérez, J., & Catalano, M. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000425 · Cited by 614 · see citing works
Self-citationSleep deprivation in depression: what do we know, where do we go?
Wirz-Justice, A., & Van den Hoofdakker, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00125-0 · Cited by 429 · see citing works
Self-citationCircadian Time of Morning Light Administration and Therapeutic Response in Winter Depression
Terman, J. S., Terman, M., Lo, E.-S., & Cooper, T. B. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.69 · Cited by 366 · see citing works
Self-citationMorning sunlight reduces length of hospitalization in bipolar depression
Benedetti, F., Colombo, C., Barbini, B., Campori, E., & Smeraldi, E. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00149-x · Cited by 341 · see citing works
Self-citationBenedetti, F., Serretti, A., Colombo, C., Barbini, B., Lorenzi, C., Campori, E., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20038 · Cited by 324 · see citing works
Self-citationSunny hospital rooms expedite recovery from severe and refractory depressions
Beauchemin, K. M., & Hays, P. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(96)00040-7 · Cited by 299 · see citing works
Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression
Colombo, C., Benedetti, F., Barbini, B., Campori, E., & Smeraldi, E. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00036-0 · Cited by 268 · see citing works
Self-citationSerretti, A., Benedetti, F., Mandelli, L., Lorenzi, C., Pirovano, A., Colombo, C., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20053 · Cited by 264 · see citing works
Self-citationKripke, D. F. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00005-6 · Cited by 221 · see citing works
Morning vs Evening Light Treatment for Winter Depression
Sack, R. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810160043008 · Cited by 182 · see citing works
Dark therapy for mania: a pilot study
Barbini, B., Benedetti, F., Colombo, C., Dotoli, D., Bernasconi, A., Cigala‐Fulgosi, M., Florita, M., & Smeraldi, E. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00166.x · Cited by 169 · see citing works
Self-citationRandomized Clinical Trial of Bright Light Therapy for Antepartum Depression: Preliminary Findings
Epperson, C. N., Terman, M., Terman, J. S., Hanusa, B. H., Oren, D. A., Peindl, K. S., & Wisner, K. L. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0319 · Cited by 167 · see citing works
Self-citationBenedetti, F., Serretti, A., Colombo, C., Campori, E., Barbini, B., di Bella, D., & Smeraldi, E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1450 · Cited by 167 · see citing works
Self-citationWehr, T. A., Turner, E. H., Shimada, J. M., Lowe, C. H., Barker, C., & Leibenluft, E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00542-8 · Cited by 162 · see citing works
Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation
Neumeister, A., Gößler, R., Lucht, M. J., Kapitany, T., Bamas, C., & Kasper, S. F. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00086-0 · Cited by 158 · see citing works
Morning Light Treatment Hastens the Antidepressant Effect of Citalopram: A Placebo-Controlled Trial
Benedetti, F., Colombo, C., Pontiggia, A., Bernasconi, A., Florita, M., & Smeraldi, E. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0605 · Cited by 152 · see citing works
Self-citationIs sleep deprivation useful in the treatment of depression?
Leibenluft, E., & Wehr, T. A. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.2.159 · Cited by 150 · see citing works
Controlled trial of bright light for nonseasonal major depressive disorders
Kripke, D. F., Mullaney, D. J., Klauber, M. R., Risch, S. C., & Gillin, J. C. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90199-a · Cited by 140 · see citing works
Colombo, C., Lucca, A., Benedetti, F., Barbini, B., Campori, E., & Smeraldi, E. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00164-5 · Cited by 139 · see citing works
Self-citationSmeraldi, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00129-8 · Cited by 116 · see citing works
Controlled trial of bright light and negative air ions for chronic depression
GOEL, N., TERMAN, M., SU TERMAN, J., MACCHI, M. M., & STEWART, J. W. (2005) · Psychological Medicine · doi:10.1017/s0033291705005027 · Cited by 115 · see citing works
Self-citationRetraction of an Interpretation
Zhang, L., Lopez, P., Tian, H., Yu, W., & Ho, D. D. (2004) · Science · doi:10.1126/science.303.5657.467b · Cited by 112 · see citing works
Benedetti, F., Barbini, B., Campori, E., Fulgosi, M. C., Pontiggia, A., & Colombo, C. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00034-6 · Cited by 110 · see citing works
Self-citationAdjunctive Bright Light in Non‐Seasonal Major Depression
Martiny, K. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00460_2.x · Cited by 105 · see citing works
Self-citation(2009) · Cited by 101 · see citing works
Riemann, D., König, A., Hohagen, F., Kiemen, A., Voderholzer, U., Backhaus, J., Bunz, J., Wesiack, B., Hermle, L., & Berger, M. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050092 · Cited by 99 · see citing works
Clinical and chronobiological effects of light therapy on nonseasonal affective disorders
Yamada, N., Martin-Iverson, M. T., Daimon, K., Tsujimoto, T., & Takahashi, S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00221-n · Cited by 98 · see citing works
Lam, R. W. M., Tam, E. M., Yatham, L. N., Shiah, I., & Zis, A. P. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00196-8 · Cited by 95 · see citing works
Self-citationOngoing Lithium Treatment Prevents Relapse After Total Sleep Deprivation
Benedetti, F., Colombo, C., Barbini, B., Campori, E., & Smeraldi, E. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199906000-00007 · Cited by 95 · see citing works
Self-citationBenedetti, F., Colombo, C., Serretti, A., Lorenzi, C., Pontiggia, A., Barbini, B., & Smeraldi, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01894-2 · Cited by 90 · see citing works
Self-citationA rapid-cycling bipolar patient treated with long nights, bedrest, and light
Wirz-Justice, A., Quinto, C., Cajochen, C., Werth, E., & Hock, C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00289-3 · Cited by 87 · see citing works
Self-citationBright light augments antidepressant effects of medication and wake therapy
Loving, R. T., Kripke, D. F., & Shuchter, S. R. (2002) · Depression and Anxiety · doi:10.1002/da.10036 · Cited by 86 · see citing works
A controlled study of light therapy in women with late luteal phase dysphoric disorder
Lam, R. W., Carter, D., Misri, S., Kuan, A. J., Yatham, L. N., & Zis, A. P. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00043-8 · Cited by 85 · see citing works
Self-citationSleep deprivation hastens the antidepressant action of fluoxetine
Benedetti, F., Barbini, B., Lucca, A., Campori, E., Colombo, C., & Smeraldi, E. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02900200 · Cited by 85 · see citing works
Self-citationSeasonal Affective Disorder: Practice and Research
EDNIE, K. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1364-a · Cited by 82 · see citing works
Sleep and manipulations of the sleep–wake rhythm in depression
Berger, M., Van Calker, D., & Riemann, D. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.17.x · Cited by 82 · see citing works
Wirz‐Justice, A., Terman, M., Oren, D. A., Goodwin, F. K., Kripke, D. F., Whybrow, P. C., Wisner, K. L., Wu, J. C., Lam, R. W. M., Berger, T., et al. (2004) · Science · doi:10.1126/science.303.5657.467c · Cited by 78 · see citing works
Self-citationSeasonal Affective Disorder and Beyond: Light Treatment for SAD and Non-SAD Conditions
(1998) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550480 · Cited by 75 · see citing works
Phototherapy in nonseasonal depression
Mackert, A., Volz, H., Stieglitz, R., & Müller-Oerlinghausen, B. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90110-8 · Cited by 72 · see citing works
Szuba, M. P., Baxter, L. R., Altshuler, L. L., Allen, E. M., Guzé, B. H., Schwartz, J. M., & Liston, E. H. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90015-9 · Cited by 69 · see citing works
Braun, D. L., Sunday, S. R., Fornari, V., & Halmi, K. A. (1999) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(99)90088-3 · Cited by 60 · see citing works
Voderholzer, U., Valerius, G., Schaerer, L., Riemann, D. W., Giedke, H., Schwärzler, F., Berger, T., & Wiegand, M. H. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0408-7 · Cited by 60 · see citing works
Light therapy for behavioural and psychological symptoms of dementia
Skjerve, A., Bjorvatn, B., & Holsten, F. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1087 · Cited by 57 · see citing works
Light therapy in bulimia nervosa: a double-blind, placebo-controlled study
Blouin, A. G., Blouin, J., Iversen, H., Carter, J., Goldstein, C., Goldfield, G. S., & Pérez, E. L. (1996) · Psychiatry Research · doi:10.1016/0165-1781(95)02532-4 · Cited by 39 · see citing works
Restless nights, listless days
Abbott, A. (2003) · Nature · doi:10.1038/425896a · Cited by 35 · see citing works
Circadian rhythm sleep disorders
Reid, K. J., Chang, A., & Zee, P. C. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.01.010 · Cited by 35 · see citing works
Future Brightening for Depression Treatments
Holden, C. (2003) · Science · doi:10.1126/science.302.5646.810 · Cited by 34 · see citing works
Pharmacological Treatment of Depressive Disorders: A Review
Bech, P. (2002) · doi:10.1002/0470861665.ch2 · Cited by 24 · see citing works
Seasonal Affective Disorder and Beyond: Light Treatment for SAD and Non-SAD Conditions.
Tam, W., & Steiner, M. S. (1999) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Wirz‐Justice, A. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00097-3 · Cited by 6 · see citing works
Self-citationSeasonal Affective Disorder and Beyond
Quinn, B. (2000) · The Primary Care Companion to The Journal of Clinical Psychiatry · doi:10.4088/pcc.v02n0206 · Cited by 3 · see citing works
Circadian rhythm sleep disorders
Billiard, M. M. (2003) · Sleep · doi:10.1007/978-1-4615-0217-3_36 · Cited by 2 · see citing works
Benefits of CBT in individuals with bipolar disorders
Scott, J. L. (2004) · Research Portal (King's College London) · Cited by 1 · see citing works
Flagged first, then by citations
3 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 13
- Benedetti, F., Colombo, C., Bernasconi, A., Barbini, B., Fulgosi, M. C., Pontiggia, A. & Smeraldi, E. (2004a). Chronobiological treatments of bipolar depression. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S14.
- Benedetti, F., Serretti, A., Colombo, C., Lorenzi, C., Tubazio, V. & Smeraldi, E. (2004 b). A glycogen synthase kinase 3-b promoter gene SNP is associated with age at onset and response to total sleep deprivation in bipolar depression. Neuroscience Letters 368, 123- 126.
- Berger, M. (2004). Sleep phase advances as a fast-acting anti- depressive strategy. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S15.
- Chisholm, D. (2004). Avertable burden of affective disorders : a global cost-effectiveness analysis. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S21.
- Kripke, D. F. (1998). Light treatment for nonseasonal depression: speed, efficacy, and combined treatment. Journal of Affective Disorders 49, 109-117.
- Martiny, K., Lunde, M., Unde´n, M., Dam, H. & Bech, P. (2004). Adjunctive bright light in non-seasonal major depression. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S16.
- Paykel, E. (2004). Long-term outcome of depression: a problem. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Dis- orders 78 (Suppl. 1), S2.
- Pinder, R. M. (2004). Do we need more antidepressants? In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S8.
- Serretti, A., Cusin, C., Benedetti, F., Mandelli, L., Pirovano, A., Zanardi, R., Colombo, C. & Smeraldi, E. (in press). Insomnia im- provement during antidepressant treatment is associated with CLOCK gene polymorphism. American Journal of Medical Genetics.
- Terman, M. (2004). Light and negative air ion treatment for chronic depression. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S15.
- Thase, M. (2004). How to achieve more remission. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S9.
- Tuunainen, A., Kripke, D. F. & Endo, T. (2004). In The Cochrane Library, vol. 2. John Wiley & Sons Ltd: Chichester, UK.
- Wu, J. C. (2004). Chronobiological augmentation of sleep depri- vation as an antidepressant intervention. In The International Society for Affective Disorders (ISAD), 2nd Biennial Conference, Cancun, Mexico. Journal of Affective Disorders 78 (Suppl. 1), S15.
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Adan, A., Archer, S. N., Hidalgo, M. P., Di Milia, L., Natale, V., & Randler, C. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719971 · Cited by 1,384 · see citing works
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Self-citationSleep Deprivation in Mood Disorders
Benedetti, F., & Colombo, C. (2011) · Neuropsychobiology · doi:10.1159/000328947 · Cited by 116 · see citing works
Self-citationOldham, C. M., & Ciraulo, D. A. (2014) · Chronobiology International · doi:10.3109/07420528.2013.833935 · Cited by 112 · see citing works
Sleep, residual mood symptoms, and time to relapse in recovered patients with bipolar disorder
Becker‐Cretu, J. J., Culver, J. L., Goffin, K. C., Shah, S., & Ketter, T. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.076 · Cited by 102 · see citing works
Circadian Rhythms, Melatonin and Depression
A. Quera Salva, M., Hartley, S., Barbot, F., C. Alvarez, J., Lofaso, F., & Guilleminault, C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796197188 · Cited by 100 · see citing works
Bipolar disorder: An evolutionary psychoneuroimmunological approach
Rantala, M. J., Luoto, S., Borráz-León, J. I., & Krams, I. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.031 · Cited by 101 · see citing works
Sartorius, N., Baghai, T. C., Baldwin, D. S., Barrett, B. M., Brand, U., Fleischhacker, W., Goodwin, G. M., Grunze, H., Knapp, M. R. J., Leonard, B. E., et al. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008255 · Cited by 98 · see citing works
Benedetti, F., Dallaspezia, S., Fulgosi, M. C., Barbini, B., Colombo, C., & Smeraldi, E. (2007) · Chronobiology International · doi:10.1080/07420520701649455 · Cited by 97 · see citing works
Self-citationChronobiological theories of mood disorder
Zaki, N. F. W., Spence, D. W., BaHammam, A. S., Pandi-Perumal, S. R., Cardinali, D. P., & Brown, G. M. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0835-5 · Cited by 95 · see citing works
Neural and Genetic Correlates of Antidepressant Response to Sleep Deprivation
Benedetti, F., Bernasconi, A., Blasi, V., Cadioli, M., Colombo, C., Falini, A., Lorenzi, C., Radaelli, D., Scotti, G., & Smeraldi, E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.179 · Cited by 92 · see citing works
Self-citationMartiny, K., Refsgaard, E., Lund, V., Lunde, M., Sørensen, L., Thougaard, B., Lindberg, L., & Bech, P. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07625 · Cited by 87 · see citing works
Self-citationCircadian Clocks and Mood-Related Behaviors
Albrecht, U. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_9 · Cited by 86 · see citing works
Lighting to Make You Feel Better: Improving the Mood of Elderly People with Affective Ambiences
Kuijsters, A., Redi, J., de Ruyter, B., & Heynderickx, I. E. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132732 · Cited by 86 · see citing works
Chronobiology, excessive daytime sleepiness and depression: Is there a link?
Chellappa, S. L., Schroder, C. M., & Cajochen, C. (2008) · Sleep Medicine · doi:10.1016/j.sleep.2008.05.010 · Cited by 84 · see citing works
Kuriyama, K., Soshi, T., & Kim, Y. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.015 · Cited by 84 · see citing works
Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models
Shi, S.-Q., Bichell, T. J., Ihrie, R. A., & Johnson, C. H. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.047 · Cited by 84 · see citing works
Geoffroy, P. A., Tebeka, S., Blanco, C., Dubertret, C., & Strat, Y. L. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.018 · Cited by 84 · see citing works
Are circadian rhythms new pathways to understand Autism Spectrum Disorder?
Geoffray, M., Nicolas, A., Speranza, M., & Georgieff, N. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2017.06.002 · Cited by 84 · see citing works
[Circadian rhythms and depression].
Soria, V., & Urretavizcaya, M. (2009) · PubMed · Cited by 83 · see citing works
Sleep Deprivation Therapy for Depression
Dallaspezia, S., & Benedetti, F. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_363 · Cited by 83 · see citing works
Self-citationRapid-acting antidepressant strategies: mechanisms of action
Bunney, B. G., & Bunney, W. E. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000927 · Cited by 79 · see citing works
O’Hare, C., O’Sullivan, V., Flood, S., & Kenny, R. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.029 · Cited by 79 · see citing works
Chronobiological therapy for mood disorders
Dallaspezia, S., & Benedetti, F. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.61 · Cited by 77 · see citing works
Self-citationRecognizing and Managing Postpartum Psychosis
Osborne, L. M. (2018) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2018.04.005 · Cited by 76 · see citing works
Sahlem, G. L., Kalivas, B., Fox, J. B., Lamb, K., Roper, A., Williams, E. N., Williams, N. R., Korte, J. E., Zuschlag, Z. D., El Sabbagh, S., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.015 · Cited by 71 · see citing works
Echizenya, M., Suda, H., Takeshima, M., Inomata, Y., & Shimizu, T. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.022 · Cited by 71 · see citing works
Scholkmann, F., Hafner, T., Metz, A. J., Wolf, M., & Wolf, U. (2017) · Neurophotonics · doi:10.1117/1.nph.4.4.045005 · Cited by 69 · see citing works
Chronobiological Therapy for Mood Disorders
Dallaspezia, S., Suzuki, M., & Benedetti, F. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0633-6 · Cited by 68 · see citing works
Self-citationZhang, T., Yu, F., Xu, H., Chen, M., Chen, X., Guo, L., Zhou, C., Xu, Y., Wang, F., Yu, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21477-w · Cited by 67 · see citing works
Brown, M. J., & Jacobs, D. E. (2011) · Public Health Reports · doi:10.1177/00333549111260s117 · Cited by 66 · see citing works
Canali, P., Papa, G. S., Casali, A. G., Schiena, G., Fecchio, M., Pigorini, A., Smeraldi, E., Colombo, C., & Benedetti, F. (2014) · Bipolar Disorders · doi:10.1111/bdi.12249 · Cited by 66 · see citing works
Self-citationBright Light Therapy in Parkinson's Disease: An Overview of the Background and Evidence
Rutten, S., Vriend, C., van den Heuvel, O. A., Smit, J. H., Berendse, H. W., & van der Werf, Y. D. (2012) · Parkinson s Disease · doi:10.1155/2012/767105 · Cited by 63 · see citing works
Artioli, P., Lorenzi, C., Pirovano, A., Serretti, A., Benedetti, F., Catalano, M., & Smeraldi, E. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.004 · Cited by 62 · see citing works
Self-citationBright Light for Weight Loss: Results of a Controlled Crossover Trial
Danilenko, K. V., Mustafina, S. V., & Pechenkina, E. A. (2013) · Obesity Facts · doi:10.1159/000348549 · Cited by 62 · see citing works
Persistent sleep disturbance is associated with treatment response in adolescents with depression
Manglick, M., Rajaratnam, S. M. W., Taffe, J. R., Tonge, B. J., & Melvin, G. A. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413481630 · Cited by 60 · see citing works
Benedetti, F., & Smeraldi, E. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788957447 · Cited by 60 · see citing works
Self-citationOutdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions
Korman, M., Tkachev, V., Reis, C., Komada, Y., Kitamura, S., Gubin, D. G., Kumar, V., & Roenneberg, T. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13471 · Cited by 57 · see citing works
Corticotropin-Releasing Hormone and Arginine Vasopressin in Depression
Bao, A., & Swaab, D. F. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)82018-7 · Cited by 60 · see citing works
Duval, F., Lebowitz, B. D., & Macher, J. P. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.2/fduval · Cited by 57 · see citing works
Alberti, S., Chiesa, A., Andrisano, C., & Serretti, A. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000329 · Cited by 59 · see citing works
LADER, M. H. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.05.004 · Cited by 59 · see citing works
Role for the<i>Clock</i>Gene in Bipolar Disorder
McClung, C. A. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.031 · Cited by 57 · see citing works
Four hygienic-dietary recommendations as add-on treatment in depression
Garcı́a-Toro, M., Ibarra, O., Gili, M., Serrano-Ripoll, M. J., Oliván‐Blázquez, B., Vicens, E., & Roca, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.031 · Cited by 57 · see citing works
Benedetti, F., Calabrese, G., Bernasconi, A., Cadioli, M., Colombo, C., Dallaspezia, S., Falini, A., Radaelli, D., Scotti, G., & Smeraldi, E. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.08.004 · Cited by 53 · see citing works
Self-citationChronobiology of mood disorders
Malhi, G. S., & Kuiper, S. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12173 · Cited by 53 · see citing works
Wirz‐Justice, A. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.024 · Cited by 51 · see citing works
Self-citationBaghai, T. C., Blier, P., Baldwin, D. S., Bauer, M., Goodwin, G. M., Fountoulakis, K. Ν., Kasper, S. F., Leonard, B. E., Malt, U. F., Stein, D. J., et al. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0259-6 · Cited by 51 · see citing works
Developmental pathways towards mood disorders in adult life: Is there a role for sleep disturbances?
Palagini, L., Domschke, K., Benedetti, F., Foster, F., Wulff, K., & Riemann, D. W. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.011 · Cited by 50 · see citing works
Self-citationAntidepressant chronotherapeutics for bipolar depression
Benedetti, F. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.4/fbenedetti · Cited by 49 · see citing works
Self-citationA multistage chronobiologic intervention for the treatment of depression: A pilot study
Moscovici, L., & Kotler, M. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.01.015 · Cited by 46 · see citing works
Jiang, W., Li, S., Liu, J.-F., Sun, Y., Zhou, S., Zhu, W., Shi, J., & Lü, L. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2941-4 · Cited by 45 · see citing works
Meta-analysis of sleep deprivation in the acute treatment of bipolar depression
Gottlieb, J. F., Goel, N., Chen, S., & Young, M. A. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13255 · Cited by 44 · see citing works
Martiny, K., Refsgaard, E., Lund, V., Lunde, M., Sørensen, L., Thougaard, B., Lindberg, L., & Bech, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067264 · Cited by 43 · see citing works
Self-citationMenculini, G., Verdolini, N., Murru, A., Pacchiarotti, I., Volpe, U., Cervino, A., Steardo, L., Moretti, P., Vieta, E., & Tortorella, A. A. V. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.071 · Cited by 44 · see citing works
Wirz‐Justice, A. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.08.003 · Cited by 43 · see citing works
Self-citationChronotherapeutics (light and wake therapy) as a class of interventions for affective disorders
(2012) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52002-9.00042-5 · Cited by 42 · see citing works
Self-citationStem Cell Factor (SCF) is a putative biomarker of antidepressant response
Benedetti, F., Poletti, S., Hoogenboezem, T. A., Locatelli, C., Ambrée, O., de Wit, H., Wijkhuijs, A. J. M., Mazza, E. B., Bulgarelli, C., Vai, B., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9672-y · Cited by 42 · see citing works
Self-citationGeographical and climatic factors and depression risk in the SUN project
Henríquez-Sánchez, P., Doreste‐Alonso, J., Martínez‐González, M. Á., Bes‐Rastrollo, M., Gea, A., & Sánchez‐Villegas, A. (2014) · European Journal of Public Health · doi:10.1093/eurpub/cku008 · Cited by 41 · see citing works
Seasonal effects on bipolar disorder: A closer look
Rosenthal, S. J., Josephs, T., Kovtun, O., & McCarty, R. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.017 · Cited by 39 · see citing works
The Acute Side Effects of Bright Light Therapy: A Placebo-Controlled Investigation
Botanov, Y., & Ilardi, S. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075893 · Cited by 40 · see citing works
Transplantability of a circadian clock to a noncircadian organism
Chen, A. H., Lubkowicz, D., Yeong, V., Chang, R. L., & Silver, P. A. (2015) · Science Advances · doi:10.1126/sciadv.1500358 · Cited by 40 · see citing works
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice
Thomas, C. W., Blanco‐Duque, C., Bréant, B. J. B., Goodwin, G. M., Sharp, T., Bannerman, D. M., & Vyazovskiy, V. V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01846-9 · Cited by 46 · see citing works
Delayed Bedtimes and Obsessive–Compulsive Symptoms
Coles, M. E., Schubert, J. R., & Sharkey, K. M. (2012) · Behavioral Sleep Medicine · doi:10.1080/15402002.2011.634939 · Cited by 38 · see citing works
Martiny, K., Refsgaard, E., Lund, V., Lunde, M., Thougaard, B., Lindberg, L., & Bech, P. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12402 · Cited by 37 · see citing works
Self-citationSelf-reported sleep disturbances in renal transplant recipients
Burkhalter, H., Brunner, D. P., Wirz‐Justice, A., Cajochen, C., Weaver, T. E., Steiger, J. U., Fehr, T. H., Venzin, R. M., & Geest, S. D. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-220 · Cited by 36 · see citing works
Self-citationValidating the Use of Wrist-Level Light Monitoring for In-Hospital Circadian Studies
Jardim, A. C. N., Pawley, M. D. M., Cheeseman, J. F., Guesgen, M. J., Steele, C. T., & Warman, G. R. (2011) · Chronobiology International · doi:10.3109/07420528.2011.611603 · Cited by 33 · see citing works
Bilu, C., Einat, H., Zimmet, P., Vishnevskia‐Dai, V., & Kronfeld‐Schor, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-76636-8 · Cited by 37 · see citing works
Afraid of the dark: Light acutely suppresses activity in the human amygdala
McGlashan, E. M., Poudel, G. R., Jamadar, S. D., Phillips, A. J. K., & Cain, S. W. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252350 · Cited by 35 · see citing works
- Authors
- WIRZ-JUSTICE, A., BENEDETTI, F., BERGER, M., LAM, R. W., MARTINY, K., TERMAN, M., & WU, J. C.
- Affiliations
- International Society for Infectious Diseases (US)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-03-10
- Volume
- 35
- Issue
- 7
- Pages
- 939-944
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2111639473
- Cited by
- 291
- References
- 58
- Citations by year
- 2026: 15 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 13 · 2019: 6 · 2018: 13 · 2017: 15 · 2016: 18 · 2015: 18 · 2014: 15 · 2013: 19 · 2012: 21
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- chronotherapy, wake therapy, phototherapy, sleep deprivation, major depressive disorder, bipolar disorder, antidepressant response, relapse prevention, seasonal affective disorder, chronic depression, antenatal depression, selective serotonin reuptake inhibitors, lithium, sleep phase advance, treatment-resistant depression
- MeSH terms
- Clinical Trials as Topic, Humans, Phototherapy, Prognosis, Treatment Outcome, Mood Disorders
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