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Cited by 645

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Neural plasticity to stress and antidepressant treatment

Open access
Duman, Ronald S, Malberg, Jessica, Thome, Johannes·1999·Biological Psychiatry
DOI 10.1016/s0006-3223(99)00177-8
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Abstract

Adaptations at the cellular and molecular levels in response to stress and antidepressant treatment could represent a form of neural plasticity that contributes to the pathophysiology and treatment of depression. At the cellular level, atrophy and death of stress-vulnerable neurons in the hippocampus, as well as decreased neurogenesis of hippocampal neurons, has been reported in preclinical studies. Clinical studies also provide evidence for atrophy and cell death in the hippocampus, as well as the prefrontal cortex. It is possible that antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of hippocampal neurons and by increasing cell survival and function. The molecular mechanisms underlying these effects are discussed, including the role of the cAMP signal transduction cascade and neurotrophic factors.

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Metadata

Authors
Duman, R. S., Malberg, J., & Thome, J.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-11
Volume
46
Issue
9
Pages
1181-1191
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(99)00177-8
OpenAlex
W2094106822
Cited by
645
References
13
FWCI
17.77
Type
journal article
Language
en
Open access
hybrid

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