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Neural plasticity to stress and antidepressant treatment
Open accessAbstract
Adaptations at the cellular and molecular levels in response to stress and antidepressant treatment could represent a form of neural plasticity that contributes to the pathophysiology and treatment of depression. At the cellular level, atrophy and death of stress-vulnerable neurons in the hippocampus, as well as decreased neurogenesis of hippocampal neurons, has been reported in preclinical studies. Clinical studies also provide evidence for atrophy and cell death in the hippocampus, as well as the prefrontal cortex. It is possible that antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of hippocampal neurons and by increasing cell survival and function. The molecular mechanisms underlying these effects are discussed, including the role of the cAMP signal transduction cascade and neurotrophic factors.
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Citations
Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Self-citationNibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Self-citationCortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395
Why stress is bad for your brain
Sapolsky, R. M. (1996) · Science · doi:10.1126/science.273.5276.749 · Cited by 1,306
Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion
Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738
Cited by
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Self-citationMayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710
Posttraumatic stress disorder: a state-of-the-science review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.005 · Cited by 675
Neuronal plasticity and survival in mood disorders
Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652
Self-citationSustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643
Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477
PICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 460
The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406
Adachi, M., Barrot, M., Autry, A. E., Theobald, D., & Monteggia, L. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.019 · Cited by 380
Jesulola, E., Micalos, P., & Baguley, I. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.025 · Cited by 379
Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339
Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329
Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324
Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., & Popoli, M. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.7 · Cited by 303
Cortisol and depression: three questions for psychiatry
Herbert, J. (2013) · Psychological Medicine · doi:10.1017/s0033291712000955 · Cited by 301
Pathophysiology of depression and mechanisms of treatment
Brigitta, B. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.1/bbondy · Cited by 286
Positron emission tomography imaging in depression: a neural systems perspective
Mayberg, H. S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00104-7 · Cited by 255
Perera, T. D., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Joyce, N., Lange, C., Higley, J. D., Rosoklija, G., Hen, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017600 · Cited by 244
Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241
Regulation of adult hippocampal neurogenesis – implications for novel theories of major depression1
Kempermann, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.40101.x · Cited by 231
Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229
Carreno, F. R., Donegan, J. J., Boley, A. M., Shah, A., DeGuzman, M., Frazer, A., & Lodge, D. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.176 · Cited by 205
Trauma, resilience and saliostasis: effects of treatment in post-traumatic stress disorder
Davidson, J. R. T., Payne, V. M., Connor, K. M., Foa, E. B., Rothbaum, B. O., Hertzberg, M. A., & Weisler, R. H. (2005) · International Clinical Psychopharmacology · doi:10.1097/00004850-200501000-00009 · Cited by 216
Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats
Guzmán‐Marín, R., Suntsova, N., Stewart, D. R., Gong, H., Szymusiak, R., & McGinty, D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041665 · Cited by 197
Neurogenesis and depression: etiology or epiphenomenon?
Henn, F. A., & Vollmayr, B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.011 · Cited by 192
Increased Waking Salivary Cortisol Levels in Young People at Familial Risk of Depression
Mannie, Z. N., Harmer, C. J., & Cowen, P. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.617 · Cited by 192
Fuchs, E., & Flügge, G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00795-5 · Cited by 188
Adolescent life events as predictors of adult depression
Pine, D. S., Cohen, P., Johnson, J. G., & Brook, J. S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00331-1 · Cited by 184
MAP Kinase Activation by Fluoxetine and Its Relation to Gene Expression in Cultured Rat Astrocytes
Mercier, G., Lennon, A. M., Renouf, B., Dessouroux, A., Ramaugé, M., Courtin, F., & Pierre, M. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:2:207 · Cited by 176
Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
Malberg, J., & Schechter, L. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382223 · Cited by 167
Self-citationXu, H., Steven Richardson, J., & Li, X.-M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300009 · Cited by 167
Delayed pharmacological effects of antidepressants
Frazer, A., & Benmansour, S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001015 · Cited by 160
Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N. A., Andersen, F., Gjedde, A., & Rosenberg, R. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02245.x · Cited by 161
van der Hart, M. G. C., Czéh, B., de Biurrun, G., Michaelis, T., Watanabe, T., Natt, O., Frahm, J., & Fuchs, E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001130 · Cited by 158
Perspectives for the development of animal models of bipolar disorder
Machado-Vieira, R., Kapczinski, F., & Soares, J. C. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.10.015 · Cited by 158
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski, P., & Duman, R. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.057 · Cited by 157
Self-citationAngelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003468 · Cited by 157
Strober, M., Freeman, R., Lampert, C., & Diamond, J. (2007) · International Journal of Eating Disorders · doi:10.1002/eat.20429 · Cited by 149
Ladd, C. O., Thrivikraman, K. V., Huot, R. L., & Plotsky, P. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.12.004 · Cited by 145
Bai, F., Bergeron, M., & Nelson, D. L. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00104-7 · Cited by 144
Czeh, B., Simon, M., van der Hart, M. G., Schmelting, B., Hesselink, M. B., & Fuchs, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300581 · Cited by 136
Hisaoka, K., Nishida, A., Koda, T., Miyata, M., Zensho, H., Morinobu, S., Ohta, M., & Yamawaki, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00531.x · Cited by 133
Dunphy-Doherty, F., O'Mahony, S. M., Peterson, V. L., O'Sullivan, O., Crispie, F., Cotter, P. D., Wigmore, P., King, M. V., Cryan, J. F., & Fone, K. C. F. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.10.024 · Cited by 124
Chen, M. J., & Russo‐Neustadt, A. A. (2009) · Hippocampus · doi:10.1002/hipo.20579 · Cited by 129
Alves, C. R. R., Merege Filho, C. A. A., Benatti, F. B., Brucki, S., Pereira, R. M. R., de Sá Pinto, A. L., Lima, F. R., Roschel, H., & Gualano, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076301 · Cited by 109
Laifenfeld, D., Karry, R., Grauer, E., Klein, E., & Ben-Shachar, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.023 · Cited by 103
Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., & Nestler, E. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08965.2000 · Cited by 101
Effects of a constant light environment on hippocampal neurogenesis and memory in mice
Fujioka, A., Fujioka, T., Tsuruta, R., Izumi, T., Kasaoka, S., & Maekawa, T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.001 · Cited by 97
Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex
Varea, E., Blasco-Ibáñez, J. M., Gómez-Climent, M. Á., Castillo-Gómez, E., Crespo, C., Martínez-Guijarro, F. J., & Nácher, J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301183 · Cited by 96
Hughes, Z. A., Liu, F., Platt, B. J., Dwyer, J. M., Pulicicchio, C. M., Zhang, G., Schechter, L. E., Rosenzweig-Lipson, S., & Day, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.03.004 · Cited by 88
Serotonergic gene expression and depression: implications for developing novel antidepressants
Lesch, K. P. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00351-7 · Cited by 93
Coplan, J. D., Gopinath, S., Abdallah, C. G., & Berry, B. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00189 · Cited by 90
iPlasticity: Induced juvenile‐like plasticity in the adult brain as a mechanism of antidepressants
Umemori, J., Winkel, F., Didio, G., Llach Pou, M., & Castrén, E. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12683 · Cited by 80
Pathobiological targets of depression
Chopra, K., Kumar, B., & Kuhad, A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553603 · Cited by 76
Diamond, D. M., Campbell, A., Park, C. R., & Vouimba, R.-M. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.003 · Cited by 71
Cellular abnormalities in depression: evidence from postmortem brain tissue
Stockmeier, C. A., & Rajkowska, G. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/cstockmeier · Cited by 67
Morphological Brain Changes in Depression: Can Antidepressants Reverse Them?
Miguel-Hidalgo, J. J., & Rajkowska, G. (2002) · CNS Drugs · doi:10.2165/00023210-200216060-00001 · Cited by 64
Bjørnebekk, A., Mathé, A. A., & Brené, S. (2010) · Hippocampus · doi:10.1002/hipo.20683 · Cited by 61
Ohashi, S., Matsumoto, M., Otani, H., Mori, K., Togashi, H., Ueno, K.-I., Kaku, A., & Yoshioka, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02973-6 · Cited by 54
Angelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A. (2003) · Neuropeptides · doi:10.1016/s0143-4179(03)00004-0 · Cited by 42
de Vasconcellos-Bittencourt, A. P. S., Vendite, D. A., Nassif, M., Crema, L. M., Frozza, R., Thomazi, A. P., Nieto, F. B., Wofchuk, S., Salbego, C., da Rocha, E. R., et al. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0404-7 · Cited by 36
Neuronal plasticity and antidepressants in the diabetic brain
Beauquis, J., Roig, P., De Nicola, A. F., & Saravia, F. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03983.x · Cited by 16
Aykaç, A., Öncül, Ş., & Onur, R. (2018) · Marmara Pharmaceutical Journal · doi:10.12991/mpj.2018.56 · Cited by 2
Metadata
- Authors
- Duman, R. S., Malberg, J., & Thome, J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 46
- Issue
- 9
- Pages
- 1181-1191
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2094106822
- Cited by
- 645
- References
- 14
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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