Cited by 559Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

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Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

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Helmchen, F., Imoto, K., Sakmann, B.·1996·Biophysical Journal

DOI 10.1016/s0006-3495(96)79653-4PMC PMC1225009

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Abstract

The effect of the fluorescent Ca2+ indicator dye Fura-2 on Ca2+ dynamics was studied in proximal apical dendrites of neocortical layer V and hippocampal CA1 pyramidal neurons in rat brain slices using somatic whole-cell recording and a charge-coupled device camera. A single action potential evoked a transient increase of intradendritic calcium concentration ([Ca2+]i) that was reduced in size and prolonged when the Fura-2 concentration was increased from 20 to 250 microM. Extrapolation to zero Fura-2 concentration suggests that "physiological" transients at 37 degrees C have large amplitudes (150-300 nM) and fast decays (time constant < 100 ms). Assuming a homogeneous compartment model for the dendrite, 0.5-1% of the total Ca2+ entering during an action potential was estimated to remain free. Washout of cytoplasmic Ca2+ buffers was not detectable, suggesting that they are relatively immobile. During trains of action potentials, [Ca2+]i increased and rapidly reached a steady state (time constant < 200 ms), fluctuating around a plateau level which depended linearly on the action potential frequency. Thus, the mean dendritic [Ca2+]i encodes the action potential frequency during physiological patterns of electrical activity and may regulate Ca(2+)-dependent dendritic functions in an activity-dependent way.

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Authors: Helmchen, F., Imoto, K., & Sakmann, B.
Affiliations: Max Planck Society (DE)
Max Planck Institute for Medical Research (DE)
ORCID: Helmchen, F.
Venue: Biophysical Journal
Publisher: Elsevier BV
Published: 1996-02
Volume: 70
Issue: 2
Pages: 1069-1081
ISSN: 0006-3495 (ISSN-L)
DOI: 10.1016/s0006-3495(96)79653-4
PMC: PMC1225009
OpenAlex: W2006602134
Cited by: 559
References: 47
Citations by year: 2026: 7 · 2025: 9 · 2024: 2 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 12 · 2016: 18 · 2015: 27 · 2014: 23 · 2013: 17 · 2012: 27
FWCI: 10.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6375 d)
Locations: Biophysical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: calcium buffering, dendritic calcium signaling, pyramidal neurons, hippocampal CA1, fura-2, calcium indicator dyes, action potential frequency
MeSH terms: Action Potentials, Animals, Biophysics, Buffers, Calcium, Cell Compartmentation, Dendrites, Fluorescent Dyes, Indicators and Reagents, Kinetics, Models, Neurological, Signal Transduction, Fura-2, Rats, Wistar, Pyramidal Cells, Rats, Biophysical Phenomena, In Vitro Techniques

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Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

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