The DOI matches its Crossref record; 132 of the 135 references it cites were found in a registry or an index.
Sensitivity to glucocorticoid-mediated fast-feedback regulation of the hypothalamic–pituitary–adrenal axis is dependent upon stressor specific neurocircuitry
Abstract
Unlabelled Fos-protein immunoreactivity (Fos-IR) was used to identify neurocircuits potentially participating in the regulation of hypothalamic-pituitary-adrenal (HPA) axis sensitivity to glucocorticoid-mediated fast-feedback in rats exposed to the physical stressor, hemorrhage, or the psychological stressor, airpuff startle. Marked regional brain differences in the Fos-IR expression were observed in response to these stressors. Specifically, after hemorrhage, nuclear Fos-IR increased in the nucleus of the solitary tract and other brainstem regions known to regulate hemodynamic processes including the supraoptic nucleus, and the magnocellular division of hypothalamic paraventricular nucleus (PVN). In contrast, after airpuff startle Fos-IR increased in the dorsomedial and lateral hypothalamus as well as in the lateral septum. Thus, activation of brainstem neurocircuits predominated after hemorrhage whereas activation of forebrain neurocircuits predominated after airpuff startle. In other regions, the magnitude of stressor-induced Fos-IR expression varied in a region-specific manner. When stressor exposure was preceded by administration of corticosterone to achieve levels within the physiological range after stressors, HPA axis responses were suppressed in response to the airpuff startle but not to either a small or moderate hemorrhage.In conclusion (1) fast-feedback mediated inhibition of HPA axis activity is critically dependent upon stressor modality; (2) this apparent selectivity is reflected by differences in the nature of the neurocircuitry mediating these stressors. It is suggested that determination of the central actions of glucocorticoids in mediating fast-feedback regulation of the HPA axis requires evaluation of the interactions between activated glucocorticoid receptors and intracellular signaling cascades evoked by convergent neuronal input.
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“At the same time, the individual components of the SRS respond in specific ways to different types of challenges (section 4), and the physiological profile of the stress response has been shown to change subtly with different types of stressors (e.g., Nair et al., 2007; Pacák and Palkovits, 2001; Thrivikraman et al., 2000).”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Thrivikraman et al., 2000
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Research works printed but not linked: 1
- Thrivikraman, 1999, HPA axis responses to stressors modulated by feedback (fbk) sensitive and resistant neurocircuitry, Soc. Neurosci. Abstr., 25, 707
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Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578
Dong, H., Petrovich, G. D., Watts, A. G., & Swanson, L. W. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1079 · Cited by 521
“Finally, it has been reported (Thrivikraman et al., 2000) that Fos levels increase in the CEAl and BSTov after hemorrhage (20% estimated blood volume).”
BackgroundPlotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522
“Jugular cannulae were implanted as previously described to allow for repeated sampling in freely moving animals (Thrivikraman et al, 2000), and a 4-day recovery period, during which time the rats were handled daily, was permitted before testing.”
MethodSelf-citation
Metadata
- Authors
- Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M.
- Affiliations
- Emory University (US)
- Corresponding author
- Thrivikraman, K.V
- ORCID
- Nemeroff, Charles B
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 870
- Issue
- 1-2
- Pages
- 87-101
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2033574728
- Cited by
- 105
- References
- 135
- Citations by year
- 2022: 3 · 2021: 3 · 2020: 1 · 2019: 4 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH042088, MH42088, MH-OD51745)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-33093)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothalamic-pituitary-adrenal axis, glucocorticoid negative feedback, Fos expression, stressor specificity, nucleus tractus solitarius, hypothalamus, lateral septum, corticosterone, glucocorticoid receptor, stress response
- MeSH terms
- Air Movements, Animals, Consciousness, Feedback, Glucocorticoids, Hemorrhage, Hypothalamo-Hypophyseal System, Male, Neural Pathways, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Receptors, Glucocorticoid, Reflex, Startle, Stress, Psychological, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Hypovolemia, Rats
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