Antibodies to the C-terminus of the β-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury

Stone, James R; Singleton, Richard H; Povlishock, John T

doi:10.1016/s0006-8993(00)02485-9

Antibodies to the C-terminus of the β-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury

Antibodies to the amyloid precursor protein (APP) are commonly used to detect traumatic axonal injury (TAI). Carried by fast anterograde axoplasmic transport, APP will pool at regions of impaired transport associated with TAI. Based primarily upon commercial antibody availability, previous studie…