The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

A pharmacokinetic analysis program (multi) for microcomputer.

Yamaoka, K., Tanigawara, Y., Nakagawa, T., & Uno, T. (1981) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.4.879 · Cited by 2,451

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750

Astrocytes induce blood–brain barrier properties in endothelial cells

Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,111

Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

Kanai, Y., Segawa, H., Miyamoto, K., Uchino, H., Takeda, E., & Endou, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23629 · Cited by 1,109

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P. J., Loffing, J., Shoemaker, C. B., & Verrey, F. (1998) · Nature · doi:10.1038/26246 · Cited by 557

Identification and Functional Characterization of a Na+-independent Neutral Amino Acid Transporter with Broad Substrate Selectivity

Segawa, H., Fukasawa, Y., Miyamoto, K., Takeda, E., Endou, H., & Kanai, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19745 · Cited by 499

Selective expression of the large neutral amino acid transporter at the blood–brain barrier

Boado, R. J., Li, J. Y., Nagaya, M., Zhang, C., & Pardridge, W. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12079 · Cited by 482

Identification of a Membrane Protein, LAT-2, That Co-expresses with 4F2 Heavy Chain, an L-type Amino Acid Transport Activity with Broad Specificity for Small and Large Zwitterionic Amino Acids

Pineda, M., Fernández, E., Torrents, D., Estévez, R., López‐Iglesias, C., Camps, M., Lloberas, J., Zorzano, A., & Palacı́n, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19738 · Cited by 407

Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells)

Yamamoto, A., Akanuma, S., Tachikawa, M., & Hosoya, K. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21991 · Cited by 43

L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain

Inyushin, M. Y., Huertas, A., Kucheryavykh, Y. V., Kucheryavykh, L. Y., Tsydzik, V., Sanabria, P., Eaton, M. J., Skatchkov, S. N., Rojas, L. V., & Wessinger, W. D. (2012) · Parkinson s Disease · doi:10.1155/2012/321406 · Cited by 43

l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

Huttunen, K. M., Huttunen, J., Aufderhaar, I., Gynther, M., Denny, W. A., & Spicer, J. A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.034 · Cited by 43

Phenylalanine-coupled solid lipid nanoparticles for brain tumor targeting

Kharya, P., Jain, A., Gulbake, A., Shilpi, S., Jain, A., Hurkat, P., Majumdar, S., & Jain, S. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-2022-6 · Cited by 43

LAT1, a novel pharmacological target for the treatment of glioblastoma

Cappoli, N., Jenkinson, M. D., Russo, C. D., & Dickens, D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115103 · Cited by 45

Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism

Kozina, E. A., Kim, A. R., Kurina, A. U., & Ugrumov, M. V. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.005 · Cited by 41

Microglia: a cellular vehicle for CNS gene therapy

Neumann, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30230 · Cited by 41

Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells

Omidi, Y., Barar, J., Ahmadian, S., Heidari, H. R., & Gumbleton, M. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1455 · Cited by 40

Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine

Yom-Tov, N., Guy, R., & Offen, D. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114535 · Cited by 42

Membrane transporters in cell physiology, cancer metabolism and drug response

Alam, S., Doherty, E., Ortega-Prieto, P., Arizanova, J., & Fets, L. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050404 · Cited by 44

The Multifaceted Role of L-Type Amino Acid Transporter 1 at the Blood–Brain Barrier: Structural Implications and Therapeutic Potential

Ahmed, H. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04506-9 · Cited by 37

Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P. A., Lipina, C., Gierliński, M., Dady, A., Singer, G., Febrer, M., Shi, Y., Yamaguchi, T. P., Taylor, P. M., et al. (2019) · EMBO Reports · doi:10.15252/embr.201948469 · Cited by 35

Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins

Pardridge, W. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114234 · Cited by 40

High- and low-affinity transport of l -leucine and l -DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1renal cells

Soares-da-Silva, P., & Serrão, P. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00030.2004 · Cited by 37

Structural basis of anticancer drug recognition and amino acid transport by LAT1

Lee, Y., Jin, C., Ohgaki, R., Xu, M., Ogasawara, S., Warshamanage, R., Yamashita, K., Murshudov, G. N., Nureki, O., Murata, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56903-w · Cited by 36

Albuterol Modulates Its Own Transepithelial Flux via Changes in Paracellular Permeability

Unwalla, H. J., Horváth, G., Roth, F., Conner, G. E., & Salathe, M. A. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0220oc · Cited by 36

Recent advances in drug and nutrient transport across the blood-retinal barrier

Kubo, Y., Akanuma, S., & Hosoya, K. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1472764 · Cited by 35

The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway

Ozaki, K., Yamada, T., Horie, T., Ishizaki, A., Hiraiwa, M., Iezaki, T., Park, G., Fukasawa, K., Kamada, H., Tokumura, K., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw3921 · Cited by 35

Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells

Kurosawa, T., Sako, D., Tega, Y., Debori, Y., Tomihara, Y., Aoyama, K., Kubo, Y., Amano, N., & Deguchi, Y. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03249-3 · Cited by 36

Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors

Alkonyi, B., Mittal, S., Zitron, I. M., Chugani, D. C., Kupsky, W. J., Muzik, O., Chugani, H. T., Sood, S., & Juhász, C. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0750-y · Cited by 36

Levodopa modulating effects of inducible nitric oxide synthase and reactive oxygen species in glioma cells

Soliman, M. K., MAZZIO, E. A., & Soliman, K. F. A. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02204-x · Cited by 36

Characterization of the human intestinal CD98 promoter and its regulation by interferon-γ

Yan, Y., Dalmasso, G., Sitaraman, S. V., & Merlin, D. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00385.2006 · Cited by 36

A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation

Porro, G., Basile, M., Xie, Z., Tuveri, G. M., Battaglia, G., & Lopes, C. D. F. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115637 · Cited by 39

Characterization of Chicken Thyroid Hormone Transporters

Bourgeois, N. M. A., Herck, S. L. J. V., Vancamp, P., Delbaere, J., Zevenbergen, C., Kersseboom, S., Darras, V., & Visser, T. J. (2016) · Endocrinology · doi:10.1210/en.2015-2025 · Cited by 36

Reduction of L-Type Amino Acid Transporter 1 mRNA Expression in Brain Capillaries in a Mouse Model of Parkinson's Disease

Ohtsuki, S., Yamaguchi, H., Kang, Y., Hori, S., & Terasaki, T. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1250 · Cited by 35

Organ-Specific Overexpression of Renal LAT2 and Enhanced Tubular l -DOPA Uptake Precede the Onset of Hypertension

Pinho, M. J., Gomes, P., Serrão, P., Bonifácio, M. J., & Soares-da-Silva, P. (2003) · Hypertension · doi:10.1161/01.hyp.0000091822.00166.b1 · Cited by 35

Gastrointestinal Dysfunction in Parkinson’s Disease

Safarpour, D., Sharzehi, K., & Pfeiffer, R. F. (2022) · Drugs · doi:10.1007/s40265-021-01664-1 · Cited by 36

LAT1 targeted brain delivery of temozolomide and sorafenib for effective glioma therapy

Zhang, Y., Cheng, Q., Xue, Y., Yao, K., Syeda, M. Z., Xu, J., Wu, J., Wang, Z., Tang, L., & Mu, Q. (2023) · Nano Research · doi:10.1007/s12274-023-5568-3 · Cited by 34

Fibre & fermented foods: differential effects on the microbiota-gut-brain axis

Schneider, E., Balasubramanian, R., Ferri, A., Cotter, P. D., Clarke, G. A., & Cryan, J. F. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124004907 · Cited by 37

The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2

Kantipudi, S., Jeckelmann, J.-M., Ucurum, Z., Bosshart, P. D., & Fotiadis, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207573 · Cited by 31

LAT-1 functions as a promotor in gastric cancer associated with clinicopathologic features

Wang, J., Chen, X., Su, L., Li, P., Liu, B., & Zhu, Z. (2013) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2013.05.003 · Cited by 31

Autoradiographic studies using l-[14C]DOPA and l-[3H]DOPA reveal regional Na+-dependent uptake of the neurotransmitter candidate l-DOPA in the CNS

Sugaya, Y., Sasaki, Y., Goshima, Y., Kitahama, K., Kusakabe, T., Miyamae, T., Kato, T., & Misu, Y. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00008-2 · Cited by 31

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Helms, H. C. C., Kristensen, M., Saaby, L., Fricker, G., & Brodin, B. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_403 · Cited by 30

Nanomedicine based strategies for oligonucleotide traversion across the blood–brain barrier

Amulya, E., Sikder, A., Vambhurkar, G. B., Shah, S., Khatri, D. K., Raghuvanshi, R. S., Singh, S. B., & Srivastava, S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.031 · Cited by 30

Practical approaches to evaluating and optimizing brain exposure in early drug discovery

Freeman, B. B., Yang, L., & Ranković, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111643 · Cited by 31

Improving the transport of chemotherapeutic drugs across the blood–brain barrier

Orthmann, A., Fichtner, I., & Zeisig, R. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.26 · Cited by 29

Hypoxia induces de‐stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells

Boado, R. J., Li, J. Y., Tsukamoto, H., & Pardridge, W. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01757.x · Cited by 28

Silencing of theWFS1gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage

Kõks, S., Overall, R. W., Ivask, M., Soomets, U., Guha, M., Vasar, E., Fernandes, C., & Schalkwyk, L. C. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2012 · Cited by 28

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug

Thiele, N. A., Kärkkäinen, J., Sloan, K. B., Rautio, J., & Huttunen, K. M. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.07.030 · Cited by 28

Treatment of Parkinson’s disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport

Pardridge, W. M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1276376 · Cited by 29

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Jakobsen, S., & Nielsen, C. U. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020197 · Cited by 28

Thyroid hormone transport across L-type amino acid transporters: what can molecular modelling tell us?

Krause, G., & Hinz, K. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.018 · Cited by 27

Carrier-mediated transportation through BBB

Khan, N. U., Miao, T., Ju, X., Guo, Q., & Han, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00006-8 · Cited by 28

Dysregulation of Astrocytic Glutamine Transport in Acute Hyperammonemic Brain Edema

Zielińska, M., Albrecht, J., & Popek, M. P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.874750 · Cited by 26

Searching for Biomarkers in the Blood of Patients at Risk of Developing Parkinson’s Disease at the Prodromal Stage

Катунина, Е. А., Blokhin, V. E., Nodel, M. R., Pavlova, E., Kalinkin, A. L., Kucheryanu, V. G., Alekperova, L., Selikhova, M. V., Martynov, M. Y., & Ugrumov, M. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031842 · Cited by 28

Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices

Foster, A. C., Rangel-Diaz, N., Staubli, U. V., Yang, J., Penjwini, M., Viswanath, V., & Li, Y. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.010 · Cited by 27

Nanophytomedicines as Therapeutic Agents for Parkinson’s Disease

Burns, J., Buck, A. C., Souza, S. D., Dube, A., & Bardien, S. (2023) · ACS Omega · doi:10.1021/acsomega.3c04862 · Cited by 26

Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood–Brain and Blood–CSF Barriers

Sekhar, G. N., Watson, C., Fidanboylu, M., Sanderson, L., & Thomas, S. A. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.003 · Cited by 25

Carrier mediated uptake of l-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)—strategy for the design of transporter/receptor targeted prodrugs

Balakrishnan, A., Jain-Vakkalagadda, B., Yang, C., Pal, D., & Mitra, A. K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00405-2 · Cited by 25

Gold Nano-/Microroses on Levodopa Microtubes for SERS-Based Sensing of Gliomas

Dube, T., Kumar, N., Kour, A., Mishra, J., Singh, M. P., Prakash, B., & Panda, J. J. (2019) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b00155 · Cited by 24

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

Kärkkäinen, J., Gynther, M., Kokkola, T., Petsalo, A., Auriola, S. O. K., Lahtela-Kakkonen, M. K., Laine, K., Rautio, J., & Huttunen, K. M. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.04.025 · Cited by 24

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

Bao, X., Wu, J., Jiang, J., Tien, A., Sanai, N., & Li, J. (2021) · Clinical and Translational Science · doi:10.1111/cts.12978 · Cited by 23

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM

Chiduza, G. N., Johnson, R. M., Wright, G. S. A., Antonyuk, S. V., Muench, S. P., & Hasnain, S. S. (2019) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798319009094 · Cited by 23

Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)

Lee, K., & Kang, Y. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0336-x · Cited by 23

Transporters in the neurohypophysial neuroendocrine system, with special reference to vesicular glutamate transporters (BNPI and DNPI): A review

Hisano, S., & Nogami, H. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10014 · Cited by 23

Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

Goldeman, C., Andersen, M. V., Al-Robai, A., Buchholtz, T., Svane, N., Ozgür, B., Holst, B., Shusta, E. V., Hall, V. J., Saaby, L., et al. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105577 · Cited by 23

Cloning and gene silencing of LAT2, the L‐3,4‐dihydroxyphenylalanine (l‐DOPA) transporter, in pig renal LLC‐PK epithelial cells

Soares-da-Silva, P., Serrão, P., PINKO, M. J., & Bonifácio, M. J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1787com · Cited by 22

Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens

Thomson, K., Morgan, I. G., Kelly, T. L., Karouta, C., & Ashby, R. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.4.25 · Cited by 20

Biologically-Derived Nanomaterials for Targeted Therapeutic Delivery to the Brain

Curley, S. M., & Cady, N. C. (2018) · Science Progress · doi:10.3184/003685018x15306123582346 · Cited by 26

Levodopa Is Associated with Reduced Development of Neovascular Age-Related Macular Degeneration

Hyman, M. J., Skondra, D., Aggarwal, N., Moir, J. T., Boucher, N., McKay, B. S., MacCumber, M. W., & Lavine, J. A. (2023) · Ophthalmology Retina · doi:10.1016/j.oret.2023.04.014 · Cited by 19

Recent Progress in Blood–Brain Barrier and Blood–CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain

Tachikawa, M., Uchida, Y., Ohtsuki, S., & Terasaki, T. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_2 · Cited by 19

Uptake of [3H]l-serine in rat brain synaptosomal fractions

Takarada, T., Balcar, V. J., Baba, K., Takamoto, A. H. R., Acosta, G. B., Takano, K., & Yoneda, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03024-5 · Cited by 18

Functionalization of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain

Alonso, M., Barcia, E., González, J. F., Montejo, C., García‐García, L., Villa-Hermosilla, M.-C., Negro, S., Fraguas‐Sánchez, A. I., & Fernández-Carballido, A. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112348 · Cited by 18

Pallidin function in Drosophila surface glia regulates sleep and is dependent on amino acid availability

Li, H., Aboudhiaf, S., Parrot, S., Scoté-Blachon, C., Benetollo, C., Lin, J., & Seugnet, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113025 · Cited by 18

Structure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)

Chen, S., Jin, C., Ohgaki, R., Xu, M., Okanishi, H., & Kanai, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-55252-w · Cited by 18

Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex

Patel, W., Rimmer, L. J., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., Pirmohamed, M., Alfirevic, A., & Dickens, D. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00727 · Cited by 18

Functional Characterization of the Solute Carrier LAT-1 (SLC7A5/SLC3A2) in Human Brain Capillary Endothelial Cells with Rapid UPLC-MS/MS Quantification of Intracellular Isotopically Labelled L-Leucine

Bay, C., Bajraktari‐Sylejmani, G., Haefeli, W. E., Burhenne, J., Weiß, J., & Sauter, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073637 · Cited by 18

Transport Mechanisms at the Blood-Cerebrospinal-Fluid Barrier: Role of Megalin (LRP2)

Spuch, C., & Fernández-Balbuena, C. N. (2010) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/1872214811004030190 · Cited by 18

Role of l -Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin

Akanuma, S., Yamakoshi, A., Sugouchi, T., Kubo, Y., Hartz, A. M. S., Bauer, B., & Hosoya, K. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00179 · Cited by 17

Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase

Flydal, M. I., Kråkenes, T.-A., Tai, M. D. S., Tran, M. P. A., Teigen, K., & Martı́nez, A. (2020) · Biochimie · doi:10.1016/j.biochi.2020.12.002 · Cited by 18

A Novel Blood-Brain Barrier-Permeable Chemotherapeutic Agent for the Treatment of Glioblastoma

Ozawa, T., Rodriguez, M. L. M., Zhao, G., Yao, T. W., Fischer, W.-N., Jandeleit, B., Koller, K. J., & Nicolaides, T. P. (2021) · Cureus · doi:10.7759/cureus.17595 · Cited by 16

Emerging Roles of Aryl Hydrocarbon Receptors in the Altered Clearance of Drugs during Chronic Kidney Disease

Machado, T. S., Cérini, C., & Burtey, S. (2019) · Toxins · doi:10.3390/toxins11040209 · Cited by 16

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

Spicer, J. A., Huttunen, K. M., Jose, J., Dimitrov, I., Akhlaghi, H., Sutton, V. R., Voskoboinik, I., & Trapani, J. A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01338 · Cited by 15

Putative roles of SLC7A5 (LAT1) transporter in pain

Alles, S. R. A., Gomez, K., Moutal, A., & Khanna, R. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100050 · Cited by 16

Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation

Kärkkäinen, J., Laitinen, T., Markowicz-Piasecka, M., Montaser, A. B., Lehtonen, M., Rautio, J., Gynther, M., Poso, A., & Huttunen, K. M. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104921 · Cited by 15

Amino acid prodrug of quinidine: An approach to circumvent P-glycoprotein mediated cellular efflux

Patel, M., Mandava, N. K., Pal, D., & Mitra, A. K. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.01.006 · Cited by 14

Changes in kinetics of amino acid uptake at the ageing ovine blood–cerebrospinal fluid barrier

Chen, R. L., & Preston, J. E. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.01.015 · Cited by 14

Toward a Systematic Structural and Functional Annotation of Solute Carriers Transporters—Example of the SLC6 and SLC7 Families

Colas, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01229 · Cited by 15

Development of Prodrugs for Treatment of Parkinson‘s Disease: New Inorganic Scaffolds for Blood–Brain Barrier Permeation

Battista, V. D., & Hey‐Hawkins, E. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.02.005 · Cited by 14

Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: A study involving the in vivo retinal uptake and vitreal pharmacokinetics of l-phenyl alanine

Atluri, H., Talluri, R. S., & Mitra, A. K. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.038 · Cited by 14

LAT1-like transporters regulate dopaminergic transmission and sleep in Drosophila

Aboudhiaf, S., Alves, G., Parrot, S., Amri, M., Simonnet, M. M., Grosjean, Y., Manière, G., & Seugnet, L. (2018) · SLEEP · doi:10.1093/sleep/zsy137 · Cited by 16

Nanodelivery of therapeutic agents in Parkinson's disease

Lafuente, J. V., Requejo, C., & Ugedo, L. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.004 · Cited by 14

Inner Blood—Retinal Barrier: Transport Biology and Methodology

Hosoya, K., & Tomi, M. (2007) · Springer eBooks · doi:10.1007/978-0-387-74901-3_14 · Cited by 13

Efficacy and Safety of Adjuvant Treatment with Entacapone in Advanced Parkinson’s Disease with Motor Fluctuation: A Systematic Meta-Analysis

Li, J., Lou, Z., Liu, X., Sun, Y., & Chen, J. (2017) · European Neurology · doi:10.1159/000479555 · Cited by 13

Non-Invasive, Targeted Nanoparticle-Mediated Drug Delivery across a Novel Human BBB Model

Kaya, S., Callan, B., & Hawthorne, S. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051382 · Cited by 12

CART modulates the effects of levodopa in rat model of Parkinson's disease.

Upadhya, M. A., Shelkar, G., Subhedar, N., & Kokare, D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.031 · Cited by 13

The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis

Ugrumov, M. V., Pavlova, E., Kolacheva, A. A., Dil’mukhametova, L. K., Bogdanov, V. V., Blokhin, V. E., & Pronina, T. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126739 · Cited by 12

Increased SLC7A8 expression mediates L-DOPA uptake by renal tubular epithelial cells

Wu, Y., Yin, Q., Su, L., Huang, X., Xia, Q., Chen, Z., Zhang, X., & Yang, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6620 · Cited by 12

Chemical Approaches for Studying the Biology and Pharmacology of Membrane Transporters: The Histidine/Large Amino Acid Transporter SLC7A5 as a Benchmark

Scalise, M., Scanga, R., Console, L., Galluccio, M., Pochini, L., & Indiveri, C. (2021) · Molecules · doi:10.3390/molecules26216562 · Cited by 12

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1)

Rautio, J., Kärkkäinen, J., Huttunen, K. M., & Gynther, M. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.09.025 · Cited by 12

Glial induction of blood‐brain barrier‐Like L‐system amino acid transport in the ECV304 cell line

Chishty, M., Reichel, A., Begley, D. J., & Abbott, N. J. (2002) · Glia · doi:10.1002/glia.10090 · Cited by 12

Translational roadmap of BBB-targeted nanoparticle strategies for neuroregenerative therapy in neurodegenerative diseases

Lee, S., Lee, J., & Lee, K. (2026) · Biomaterials Science · doi:10.1039/d5bm01582k · Cited by 11

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Capuz, A., Osien, S., Karnoub, M., Aboulouard, S., Laurent, E. M. N., Coyaud, É., Raffo‐Romero, A., Duhamel, M., Bonnefond, A., Derhourhi, M., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05737-9 · Cited by 11

The Effects of Prodrug Size and a Carbonyl Linker on l ‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake

Venteicher, B., Merklin, K., Ngo, H., Chien, H., Hutchinson, K., Campbell, J., Way, H., Griffith, J., Alvarado, C., Chandra, S., et al. (2020) · ChemMedChem · doi:10.1002/cmdc.202000824 · Cited by 11

Inner Blood–Retinal Barrier Mediates L-Isomer-Predominant Transport of Serine

Tachikawa, M., Okamoto, M., Hirose, S., Yoneyama, D., Akanuma, S., Terasaki, T., & Hosoya, K. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22626 · Cited by 11

Medicinal Chemistry Challenges in CNS Drug Discovery

Bingham, M. J., & Ranković, Z. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734943-00465 · Cited by 11

Designing CNS Drugs for Optimal Brain Exposure

Ranković, Z. (2015) · doi:10.1002/9781118788523.ch18 · Cited by 11

Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction

Li, Y.-X., Yang, J., Alcantara, M., Abelian, G., Kulkarni, A. A., Staubli, U. V., & Foster, A. C. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.251116 · Cited by 10

The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study

Brust, P., Vorwieger, G., Walter, B. L., Füchtner, F., Stark, H., Kuwabara, H., Herzau, M., Opfermann, T., Steinbach, J., Ganapathy, V., et al. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.07.002 · Cited by 10

The Role of Biological Rhythms in New Drug Formulations to Cross the Brain Barriers

Mineiro, R., Albuquerque, T., Neves, A. R., Santos, C. R. A., Costa, D. R. B., & Quintela, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612541 · Cited by 10

Enzymic activity of the brain: microvessels vs. total forebrain homogenate

Djuričić, B. M., & Mruˇlja, B. B. (1977) · Brain Research · doi:10.1016/0006-8993(77)90694-1 · Cited by 65

Expression of a system L neutral amino acid transporter at the blood–brain barrier

Matsuo, H., Tsukada, S., Nakata, T., Chairoungdua, A., Kim, D. K., Ho, S., Inatomi, J., Yorifuji, H., Fukuda, J., Endou, H., et al. (2000) · Neuroreport · doi:10.1097/00001756-200011090-00021 · Cited by 147

SYNTHETIC AMINO ACIDS AND THE NATURE OF l ‐DOPA TRANSPORT AT THE BLOOD‐BRAIN BARRIER

Wade, L. A., & Katzman, R. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb04415.x · Cited by 211

Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-l-DOPA11Abbreviations: AAAD, aromatic l-amino acid decarboxylase; BBB, blood-brain barrier; BUI, brain uptake index; carbidopa, l-α-hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid; l-DOPA, l-3,4-dihydroxyphenylalanine; FDA, 6-fluorodopamine; [18F]FDOPA, 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine; 4-[18F]FMT, 4-[18F]fluoro-l-meta-tyrosine; 6-[18F]FMT, 6-[18F]fluoro-l-meta-tyrosine; MeAIB, α-(methylamino)isobutyric acid; MPTP, 1-methyl-1,2,3,6-tetrahydropyridine; PD, Parkinson’s disease; PET, positron emission tomography; and PLP, pyridoxal phosphate.

Yee, R. E., Cheng, D. W., Huang, S.-C., Namavari, M., Satyamurthy, N., & Barrio, J. R. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00787-0 · Cited by 35

Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK1 cells

Soares-da-Silva, P., & Serrão, P. (2005) · Amino Acids · doi:10.1007/s00726-005-0242-5 · Cited by 5