The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer’s disease
Abstract
Advanced glycation end products (AGE) and the receptor for AGE (RAGE) have been implicated in the chronic complications of diabetes mellitus (DM), and have been reported to play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we established a polyclonal anti-RAGE antibody, and examined the immunohistochemical localization of amyloid beta protein (Abeta), AGE, and RAGE in neurons and astrocytes from patients with AD and DM. Our anti-RAGE antibody recognized full-length RAGE (50 kd) and N-terminal RAGE (35 kd) in human brain tissue. Abeta-, AGE-, and RAGE-positive granules were identified in the perikaryon of hippocampal neurons (especially from CA3 and CA4) in all subjects. The distribution and staining pattern of these immunopositive granules showed good concordance with each antibody. In AD, most astrocytes contained both AGE-and RAGE-positive granules and their distribution was almost the same. Abeta-positive granules were less common, but Abeta-, AGE-, and RAGE-positive granules were colocalized in one part of a single astrocyte. In DM patients and control cases, AGE-and RAGE-positive astrocytes were very rare. These finding support the hypothesis that glycated Abeta is taken up via RAGE and is degraded through the lysosomal pathway in astrocytes. In addition to the presence of AGE, the process of AGE degradation and receptor-mediated reactions may contribute to neuronal dysfunction and promote the progression of AD.
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“Our previous research and that of others found that RAGE receptors are overexpressed in the BBB and astrocytes, especially in brain tissue from AD animal models and AD patients.33–35”
From Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration (2026) · cites this paper as [34]
In the citing paper
“AGEs and the receptor for advanced glycation end-products (RAGE) can play an important role in AD pathogenesis as higher levels of RAGE expression in neuronal, microglial, and endothelial cells in patients with AD compared with age-matched, non- demented controls are found [43,44,45,46].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [46]
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Metadata
- Authors
- Sasaki, N., Toki, S., Chowei, H., Saito, T., Nakano, N., Hayashi, Y., Takeuchi, M., & Makita, Z.
- Affiliations
- Sapporo Medical University (JP)
- Hokuriku University (JP)
- Kurume University (JP)
- Corresponding author
- Sasaki, Nobuyuki
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 888
- Issue
- 2
- Pages
- 256-262
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2091657472
- Cited by
- 253
- References
- 29
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 15 · 2020: 13 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 20 · 2012: 8
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- receptor for advanced glycation end products, advanced glycation end products, Alzheimer's disease, amyloid-beta, astrocytes, hippocampal neurons, diabetes mellitus, lysosomal degradation, colocalization, neuronal dysfunction
- MeSH terms
- Receptor for Advanced Glycation End Products, Aged, Alzheimer Disease, Animals, Antibody Specificity, Astrocytes, Cattle, Diabetes Mellitus, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Receptors, Immunologic, Blotting, Western, Amyloid beta-Peptides, Glycation End Products, Advanced
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