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Cited by 99Acute Ischemic Stroke ManagementNeurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record.

Aging has a complex effect on a rat model of ischemic stroke

Shapira, Shlomo, Sapir, Michal, Wengier, Ada, Grauer, Ettie, Kadar, Tamar·2002·Brain Research
DOI 10.1016/s0006-8993(01)03270-x
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Abstract

Stroke in humans is usually associated with advanced age. Nevertheless, almost all animal models of ischemic stroke are based on young animals. The present study was designed to assess the effect of age on the development of ischemic injury in a model of focal brain ischemia in rats. Two age groups of Wistar rats were used: young adult (3 months) and old (24-26 months). Under halothane anesthesia, polyethylene microspheres (50 microm in diameter) were injected into the left common carotid artery following a temporary occlusion of the external carotid artery. Sham-operated rats underwent the same procedure but were injected with an identical volume (100 microl) of saline only. Rats of both experimental groups displayed neurological impairment after surgery. However, contrary to expectation, the young rats were more affected than the old rats. Young rats displayed an abrupt 30% decrement in neurological functions in the first week and then showed a partial functional recovery into a 12% decrement from the second week on. Old rats developed the neurological impairment gradually over a 2-week period (6.3% in the first week and 11% in the second week and thereafter). One month later, rats were tested in a water maze task. Again, performance was more impaired in the young ischemic rats than in the old rats. Histological evaluation revealed more extensive neurological damage in young ischemic as compared to old rats. Thus, although increased age has a critical effect on the evolutio…

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Metadata

Authors
Shapira, S., Sapir, M., Wengier, A., Grauer, E., & Kadar, T.
Affiliations
Israel Institute for Biological Research (IL)
Corresponding author
Shapira, Shlomo
ORCID
Grauer, Ettie
Venue
Brain Research
Publisher
Elsevier BV
Published
2002-01
Volume
925
Issue
2
Pages
148-158
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(01)03270-x
OpenAlex
W1994270967
Cited by
99
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 2 · 2013: 10 · 2012: 1
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
aging, ischemic stroke, focal cerebral ischemia, neurological deficit, functional recovery, water maze performance, carotid artery occlusion, polyethylene microspheres, animal models of stroke, Wistar rats
MeSH terms
Aging, Animals, Body Weight, Brain, Carotid Arteries, Brain Ischemia, Cognition, Disease Models, Animal, Male, Microspheres, Motor Activity, Neurologic Examination, Reflex, Rats, Wistar, Disease Progression, Maze Learning, Recovery of Function, Stroke, Rats

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