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Cited by 30Sleep and Wakefulness ResearchEpilepsy research and treatmentNeuroscience of respiration and sleep

Correlation between the fighting rates of REM sleep-deprived rats and susceptibility to the 'wild running' of audiogenic seizures

de Paula, Hugo Medeiros Garrido, Hoshino, Katsumasa·2002·Brain Research
DOI 10.1016/s0006-8993(01)03306-6
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Abstract

Sleep-deprived rats exhibit defensive fighting as well as explosive flights very similar to the wild-running of audiogenic seizures. In order to determine why sleep deprivation is a common factor that facilitates both panic and convulsive manifestations, the present study was undertaken to investigate whether rats that display sleep deprivation-induced fighting (SDIF) are the same as those that are susceptible to audiogenic wild-running (WR). Twenty-eight male adult Wistar rats were divided into two groups assigned to two experimental schemes. In the first, 18 subjects were submitted to REM-sleep deprivation for 5 days and had their SDIF evaluated in social grouping. After 1 week for recovery, their susceptibility to WR was tested in an acoustic stimulation trial (104 dB, 200 Hz, 60 s). Rats that did not present WR received a lactate infusion and were tested again by acoustic stimulation 40 min later. In the second experimental scheme, 10 subjects were initially evaluated for WR susceptibility and the number of SDIF was recorded in social grouping after 1 week. Three categories of WR-susceptibility were determined: WR-sensitive rats, intermediate WR-sensitive rats and WR-insensitive rats. The number of SDIF in each category was significantly different and there was a high positive correlation (r=0.89; Spearman test) between the number of SDIF and the level of WR-susceptibility. We conclude that the reasons why sleep deprivation exerts facilitatory effects on both panic and convulsive manifestations are due to overlappings of neural pathways responsible for both behavioral patterns and for the property of sleep deprivation to increase neuronal excitability.

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  • Increases in fighting behavior are observed following REM sleep deprivation.

    “Increases in fighting behavior are observed following REM sleep deprivation71”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [71]

  • Sleep deprivation is associated with increases in fighting behavior after deprivation of REM sleep, and increased aggression in the form of muricide after phencyclidine administration after sleep deprivation.

    “Sleep deprivation has also been associated with increases in fighting behavior after deprivation of rapid eye movement (REM) sleep;37 there is also a report of increased aggression in the form of muricide after phencyclidine administration after sleep deprivation.38”

    From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [37]

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Authors
de Paula, H. M. G., & Hoshino, K.
Affiliations
Universidade Estadual Paulista (Unesp) (BR)
Corresponding author
Hoshino, Katsumasa
Venue
Brain Research
Publisher
Elsevier BV
Published
2002-02
Volume
926
Issue
1-2
Pages
80-85
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(01)03306-6
OpenAlex
W2098929065
Cited by
30
References
44
Citations by year
2025: 1 · 2022: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 1
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Funders
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
REM sleep deprivation, audiogenic seizures, seizure susceptibility, panic, neuronal excitability, lactate infusion, auditory stimulation
MeSH terms
Acoustic Stimulation, Aggression, Animals, Lactates, Male, Neural Pathways, Panic, Sleep Deprivation, Rats, Wistar, Epilepsy, Reflex, Rats

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