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Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats
Abstract
Disinhibition of neurons in the dorsomedial hypothalamus (DMH) by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) elicits a range of autonomic and endocrine changes resembling those seen in experimental paradigms for emotional stress. Stress in rats is also known to provoke increases in body temperature resulting in part from sympathetically mediated activation of brown fat. The purpose of the present study was to examine the effect of microinjection of BMI into the DMH on core body temperature and temperature of brown fat in rats. In anesthetized preparations, microinjection of BMI 10 pmol/50 nl into the DMH and adjoining posterior hypothalamus elicited marked and rapid increases in temperature in interscapular brown adipose tissue (IBAT) and lesser delayed elevations in rectal temperature. Similar injections into the paraventricular nucleus or ventromedial hypothalamus had no effect on either parameter. Peak increases in IBAT were significantly correlated with both peak increases in core temperature and maximal increases in heart rate that accompanied these changes, and all of these effects were abolished by systemic treatment with propranolol 1 mg/kg. In conscious rats instrumented for telemetry, microinjection of BMI 10 pmol/100 nl into the DMH evoked marked increases in core temperature as well as heart rate, locomotor activity, and plasma ACTH. The increase in core temperature occurred with a delayed time course similar to that seen in anesthetized preparations. These results indicate that activation of neurons in the DMH provokes increases in body temperature resulting in large part from sympathoadrenally-mediated activation of brown fat.
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“For example, a chemical stimulation of this area increases the thermogenic response in rats 81.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [81]
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Metadata
- Authors
- Zaretskaia, M. V., Zaretsky, D. V., Shekhar, A., & DiMicco, J. A.
- Affiliations
- Indiana University Indianapolis (US)
- Corresponding author
- DiMicco, Joseph A.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 928
- Issue
- 1-2
- Pages
- 113-125
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1986410493
- Cited by
- 173
- References
- 61
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 5 · 2012: 4
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Neurological Disorders and Stroke (NS-19883, R01NS019883)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dorsomedial hypothalamus, non-shivering thermogenesis, bicuculline methiodide, GABA-A receptor antagonism, brown adipose tissue, interscapular brown adipose tissue, core body temperature, sympathetic activation, propranolol, ACTH, heart rate, emotional stress, hypothalamic neurons
- MeSH terms
- Adrenal Medulla, Adrenergic beta-Antagonists, Adrenocorticotropic Hormone, Animals, Bicuculline, Blood Pressure, Body Temperature, Adipose Tissue, Brown, Dorsomedial Hypothalamic Nucleus, gamma-Aminobutyric Acid, Heart Rate, Male, Motor Activity, Neural Inhibition, Neurons, Propranolol, Receptors, Adrenergic, beta, Receptors, GABA-A, Sympathetic Nervous System, Rats, Sprague-Dawley, GABA Antagonists, Thermogenesis, Rats, GABA-A Receptor Antagonists
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