Thermogenic mechanisms in brown fat.
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UCP1 plays a role in adaptive thermogenesis in mammalian brown adipose tissue to produce heat.
“UCP1 plays a role in adaptive thermogenesis in mammalian brown adipose tissue to produce heat (314), whereas the actions of UCP2 and 3 are upregulated in response to oxidant stress caused by nutrient deprivation, glucose sensing, fatty acid metabolism, or other metabolic changes in order to lessen mitochondrial ROS production (49).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [314]
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“However, whether in tissues differently from BAT UCP1 homologues are responsible for mitochondrial basal or inducible proton conductance is yet controversial [280].”
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“UcP1 is mainly expressed in BAT, which converts stored energy in Δ p into heat for thermogenesis (151).”
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“This is mainly thanks to the increase in brown fat proliferation and differentiation, which result in the increase in UCP1 expression and the expansion of mitochondrial mass per cell in rodent models (Himms-Hagen et al., 1981; Rothwell and Stock, 1979).”
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“This effect of GDP on membrane potential can be interpreted as an inhibition of the active proton translocating UCP1 and, concomitantly, a slowing down of 02 consumption, as previously demonstrated (8).”
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“, its proton conductance, is blocked by nucleotides and strikingly augmented by fatty acids (168, 186).”
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“355 Exemplary of this phenomenon, mitochondria in brown adipocytes express high levels of UCP1 that increases proton leak across the IMM, accelerating upstream heat-producing biochemical reactions in a Ca 2+ -dependent manner.”
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“UCP1 plays a role in adaptive thermogenesis in mammalian brown adipose tissue to produce heat (314), whereas the actions of UCP2 and 3 are upregulated in response to oxidant stress caused by nutrient deprivation, glucose sensing, fatty acid metabolism, or other metabolic changes in order to lessen mitochondrial ROS pr…”
BackgroundMitochondrial Energetics in the Heart in Obesity-Related Diabetes
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“UCP1-mediated uncoupling of brown adipose tissue is well accepted (13).”
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“UCPs are mitochondrial transporters that have the capacity to dissipate the proton gradient and thereby produce heat (21).”
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“The dissipation of energy stored in the form of the mitochondrial electrochemical proton gradient by nonesterified fatty acids is of particular importance in brown adipose tissue, which is the unique thermogenic organ in mammals (Nicholls and Locke, 1984).”
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“BAT, brown adipose tissue; EST, expressed sequence tag; FACS, fluorescence-activated cell sorter; NST, nonshivering thermogenesis; PCR, polymerase chain reaction; RACE, rapid amplification of cDNA ends; SC, synthetic complete; UCP, uncoupling protein; UCPH, UCP homolog.”
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“It is well-known that brown adipose tissue (BAT) plays a vital role in the prevention and treatment of obesity [155].”
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“In brown adipose tissue of rodents, UCP-1 dissipates the energy of substrate oxidation as heat (Nicholls & Locke, 1984).”
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“Uncoupling protein (UCP) or thermogenin is the product of a gene uniquely expressed in this tissue and is the key element for its thermogenic function (47^49).”
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Oelkrug, R., Polymeropoulos, E. T., & Jastroch, M. (2015) · Journal of Comparative Physiology B · doi:10.1007/s00360-015-0907-7 · Cited by 283 · see citing works
“It is broadly accepted that BAT is the major source of adaptive NST in modern eutherian mammals (Nicholls and Locke 1984; Cannon and Nedergaard 2004).”
BackgroundParadoxical resistance to diet-induced obesity in UCP1-deficient mice
Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315737 · Cited by 281 · see citing works
Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue
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“• Induction of the mitochondrial uncoupling protein 1 (UCP1) [13], which leads to an increased resting energy expenditure (REE) by uncoupling a step during cellular metabolism [14].”
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“They focused on the elevation of mitochondrial ROS during BAT thermogenesis and established that thermogenic ROS alters the redox status of cysteine thiols in BAT to drive increased respiration and that Cys-253 of UCP1 is a key target [78,79].”
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A century of mitochondrial research: achievements and perspectives
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“UCP-1 or thermogenin was discovered in brown adipose tissue where it serves as a proton leak to uncouple electron transport from ATP synthesis and hence in thermoregulation in newborns and hibernating animals (Matthias et al., 1999; Nedergard and Cannon, 1992; Nicholls and Locke, 1984; Nicholls and Rial, 1999; Silva a…”
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Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15737 · Cited by 265 · see citing works
“By expecting UCP1-deficient mice to have increased susceptibility to obesity, we have failed to appreciate that brown fat in the mouse and rat is extraordinarily efficient at generating heat (25, 26).”
BackgroundGenetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
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Mitochondria in the diabetic heart
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“In the brown adipose tissue, mitochondrial uncoupling is mediated by uncoupling protein 1 (UCP1) and serves non-shivering thermogenesis.(41) UCP1 is an H+ translocase, which channels protons from the intermembrane space back into the matrix space, thereby bypassing the F0F1-ATPase, reducing ATP production with the gen…”
Background
- Authors
- Nicholls, D. G., & Locke, R. M.
- ORCID
- Nicholls, D G
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1984-01
- Volume
- 64
- Issue
- 1
- Pages
- 1-64
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1900866157
- Cited by
- 1,602
- References
- 0
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 24 · 2023: 21 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 34 · 2018: 40 · 2017: 36 · 2016: 45 · 2015: 35 · 2014: 42 · 2013: 38 · 2012: 34
- FWCI
- 44.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, thermogenesis, non-shivering thermogenesis, UCP1, mitochondrial respiration, energy expenditure
- MeSH terms
- Adaptation, Physiological, Cyclic AMP, Adenosine Triphosphate, Animals, Biomechanical Phenomena, Body Temperature Regulation, Adipose Tissue, Brown, Carrier Proteins, Cyclic AMP Receptor Protein, Cell Physiological Phenomena, Central Nervous System, Chlorides, Cytosol, Diet, Fatty Acids, Cricetinae, Hibernation, Hydrogen-Ion Concentration, Insulin, Lipolysis, Mitochondria, Obesity, Oxidation-Reduction, Permeability, Protein Kinases, Proteins, Protons, Receptors, Adrenergic, beta, Respiratory Physiological Phenomena, Sympathetic Nervous System, Thyroid Hormones, Time Factors, Mice, Rats
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