Astroglial interlaminar processes in human cerebral cortex: Variations in cytoskeletal profiles.
Abstract
Among mammalian species, astroglial interlaminar processes are unique features of the primate cerebral cortex. The morphological diversity in the immunocytochemical expression of their cytoskeleton was analyzed. For this purpose, samples from normal human cerebral cortex from autopsy cases were used. While Fractal dimension failed to represent the actual complexity of interlaminar processes, Compression analysis allowed classification of these profiles according to their relative tortuosity. Conversion of Compression values into estimates of membrane surface suggested that profile changes could not only affect the directionality of dynamic events, but also the amount of glial cell membrane exposed to the local neuropil. Terminal segments of interlaminar processes were usually more tightly twisted than the cytoskeleton stalk, and enlarged in aged individuals. If not aberrant structures, these so-called 'terminal masses' may provide an additional means to increase local membrane availability. Based on Compression analysis, categories of the geometric variability of the cytoskeleton of cerebral cortex interlaminar glial processes are presented.
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Astrocytes are directly involved in synaptic connections and control, ranging from ionic balance to the genesis and behavior of synapses.
“Evidence now shows that astrocytes are directly involved in synaptic connections and control, ranging from ionic balance to the genesis and behavior of synapses”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Reisin and Colombo, 2002
The ends of longer ILA processes are varicose-like, creating a club-ending that may increase membrane surface availability.
“The ends of the longer processes is also varicose-like, creating a club-ending that may increase membrane surface availability”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Reisin and Colombo, 2002
Long interlaminar processes show three main morphologies: mostly rectilinear, mostly sinuous, and an intermediate morphology.
“They identified three main morphologies typical of the long interlaminar processes: (i) mostly rectilinear, following a straight direction, (ii) mostly sinuous, with changes of direction, and (iii) an intermediate morphology, following a single direction with some curvature”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Reisin and Colombo, 2002
Reisin and Colombo (2002) described three different morphologies for the long interlaminar processes, suggesting regional adaptation of ILAs.
“The first attempt was performed by Reisin and Colombo (2002), trying to describe three different morphologies for the long interlaminar processes, suggesting regional adaptation of ILAs (Reisin and Colombo, 2002).”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Reisin and Colombo, 2002
Cites
Interlaminar Astroglial Processes in the Cerebral Cortex of Adult Monkeys But Not of Adult Rats
Colombo, J. A. (1996) · Cells Tissues Organs · doi:10.1159/000147790 · Cited by 45 · see citing works
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Functional diversity of astrocytes in neural circuit regulation
Haim, L. B., & Rowitch, D. H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.159 · Cited by 618 · see citing works
Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain
Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., & Goldman, J. E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-13.2014 · Cited by 185 · see citing works
Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain
Ciani, C., & Falcone, C. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1477753 · Cited by 11 · see citing works
- Authors
- Reisin, H. D., & Colombo, J. A.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- ORCID
- Colombo, Jorge A
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 937
- Issue
- 1-2
- Pages
- 51-57
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1973210880
- Cited by
- 15
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 1 · 2018: 1 · 2016: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS31862)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Keywords
- human cerebral cortex, cytoskeleton, fractal dimension, membrane surface, aging, primate cerebral cortex, glial morphology
- MeSH terms
- Aging, Astrocytes, Cerebral Cortex, Cytoskeleton, Glial Fibrillary Acidic Protein, Humans, Image Processing, Computer-Assisted, Mathematics, Fractals, Neuropil, Cell Size
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