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Cited by 45Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsMedical and Biological Sciences

Interlaminar Astroglial Processes in the Cerebral Cortex of Adult Monkeys But Not of Adult Rats

Colombo, J.A.·1996·Cells Tissues Organs
DOI 10.1159/000147790
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Abstract

Three adult Cebus apella and two Saimiri sciureus monkeys, as well as four adult rat brains were processed for glial fibrillary acid protein (GFAP) immunocytochemistry. Irregular patches with relatively abundant, long astrocytic processes were found in monkey but not in rat brains, along the cingulate, as well as orbital, medial and dorsolateral cortices of the frontal lobe, and in temporal lobe cortical areas. The observed long astrocytic processes alternated in an apparent irregular fashion with others with a predominantly clear background and scattered GFAP-immunoreactivity (IR) astrocytes or with a predominant GFAP-IR-dense fibrillary meshwork. They usually stemmed from lamina I or II and coursed through deep laminae. Entorhinal cortex in rat brains showed occasional astroglial processes somewhat longer than those commonly observed in other cortical regions, albeit significantly shorter than those observed in Ceboidea monkeys and not truly interlaminar. These observations indicate a clear morphological difference in astroglial organization between nonhuman primates and a rodent brain. They further show that ‘interlaminar astrocytes’ are distributed nonhomogeneously in the frontal cortex of New World monkeys. No interlaminar processes were observed in cortical areas of rat brains. Even though the physiological role of interlaminar astrocytes in a primate brain remains unknown, their significant departure from the morphology of classical, stellate astrocytes suggest that they may subserve different cortical requirements.

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Crossref · 10.1159/000147790

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  • ILAs are characterized by one or more long processes that may enter the deeper cortex, take a diagonal or tangential direction, remain in the superficial laminae, or not exit their cortical layer.

    “ILAs are characterized by one or more long processes that may enter the deeper cortex, take a diagonal or tangential direction, remain in the superficial laminae, or even not exit their cortical layer”

    From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo, 1996

  • The columnar morphology of ILAs may indicate a role in trafficking and integrating information from superficial layers to deep layers, and in horizontal interactions via short processes that do not exit layers I and II.

    “The columnar morphology of ILAs may indicate a role in trafficking and integrating information from the superficial layers to the deep ones, as well as in horizontal interactions via short processes that do not exit layers I and II (Colombo, 1996).”

    From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo, 1996

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Authors
Colombo, J. A.
Affiliations
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
Colombo, J.A.
ORCID
Colombo, J.A.
Venue
Cells Tissues Organs
Publisher
S. Karger AG
Published
1996
Volume
155
Issue
1
Pages
57-62
ISSN
  • 1422-6405 (ISSN-L)
  • 1422-6421
DOI
10.1159/000147790
OpenAlex
W2048478625
Cited by
45
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 4 · 2017: 1 · 2016: 3 · 2013: 5
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cells Tissues Organs (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consejo Nacional de Investigaciones Científicas y Técnicas
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
Keywords
glial fibrillary acidic protein, cerebral cortex, New World monkeys, Cebus apella, Saimiri sciureus, rat brain, frontal lobe, entorhinal cortex, cortical layers, astrocyte morphology
MeSH terms
Animals, Astrocytes, Cebus, Cerebral Cortex, Female, Glial Fibrillary Acidic Protein, Immunohistochemistry, Male, Saimiri, Species Specificity, Rats, Sprague-Dawley, Rats

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