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β-Amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes

Deb, Suman, Wenjun Zhang, J., Gottschall, Paul E.·2003·Brain Research
DOI 10.1016/s0006-8993(03)02344-8
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Abstract

The senile and neuritic plaque neuropathology of Alzheimer's disease (AD) is accompanied by an inflammatory response that includes activated astrocytes and microglia. Activated mononuclear phagocytes and reactive astrocytes, in response to inflammatory cytokines, secrete a set of extracellular matrix (ECM)-degrading enzymes that include the matrix metalloproteinases (MMPs). The major peptide component of senile plaques of AD, beta-amyloid (Abeta), stimulates the production of several MMPs from cultured rat astrocytes and microglia. The purpose of this study was two-fold: (1) to compare the pattern of MMP induction in rat astrocytes on treatment with 'soluble' and 'fibrillar' Abeta(1-40) and Abeta(1-42), and (2) to examine whether treatment of astrocytes with Abeta results in degraded fragments of ECM. Abeta aggregation differentially affected the production of MMP-2 and MMP-9 in astrocyte cultures. Activation experiments with amino phenyl mercuric acetate suggested that the 52-54 kDa gelatin-degrading activity was an activated form of MMP-2. In addition, Abeta peptide induced both MMP-3 and plasminogen activator-like activity from astrocytes. When medium from Abeta-treated, astrocyte cultures was immunoblotted for fibronectin, several immunopositive, lower molecular weight bands were observed as compared to untreated conditioned medium, suggestive of the presence of an active fibronectin-degrading protease. Thus, Abeta induces the secretion of several matrix-degrading proteas…

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Crossref · 10.1016/s0006-8993(03)02344-8

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  • Some MMPs may play an important role in degrading soluble Ab, such as secreted MMP-2 and MMP-9 that generate C-terminally truncated Ab fragments and membrane-type MMP-14 that degrades both soluble and fibrillary Ab.

    “Increasing in vitro evidence indicates that some MMPs may play an important role in degrading soluble Ab (sAb), such as secreted MMP-2 and MMP-9 that generate C-terminally truncated Ab fragments and membrane-type MMP-14 that degrades both soluble and fibrillary Ab (29)(30)(31)(32).”

    From Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia (2017) · cites this paper as [30]

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Metadata

Authors
Deb, S., Wenjun Zhang, J., & Gottschall, P. E.
Venue
Brain Research
Publisher
Elsevier BV
Published
2003-04
Volume
970
Issue
1-2
Pages
205-213
ISSN
0006-8993
DOI
10.1016/s0006-8993(03)02344-8
Cited by
81
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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