Cited by 2,178Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingDementia and Cognitive Impairment Research

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

Jarrett, Joseph T., Lansbury, Peter T.·1993·Cell

Integrity signals

Registry

Crossref · 10.1016/0092-8674(93)90635-4

Cites

4 of 4 references verified0 citation errors · 0 not checkable

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  • Aβ1-42 forms insoluble amyloid fibrils more rapidly than Aβ1-40.

    “A{31-42 has been shown to form insoluble amyloid fibrils more rapidly than A{31-40 (10)(11)(12)(13).”

    From Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain (1995) · cites this paper as [12]

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Authors
Jarrett, J. T., & Lansbury, P. T.
Affiliations
Massachusetts Institute of Technology (US)
Venue
Cell
Publisher
Elsevier BV
Published
1993-06
Volume
73
Issue
6
Pages
1055-1058
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2059804089
Cited by
2,178
References
4
Citations by year
2026: 19 · 2025: 30 · 2024: 36 · 2023: 47 · 2022: 58 · 2021: 59 · 2020: 61 · 2019: 58 · 2018: 71 · 2017: 83 · 2016: 68 · 2015: 77 · 2014: 79 · 2013: 82 · 2012: 93
FWCI
8.44
Type
journal article
Language
en
Open access
closed
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, scrapie, amyloid fibril formation, protein aggregation, prion protein, amyloid plaques, Creutzfeldt-Jakob disease, prion disease, pathophysiological mechanisms, neurodegeneration, protein crystallization, microtubule formation, rate-determining step
MeSH terms
Alzheimer Disease, Amyloid, Animals, Humans, Scrapie

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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