Cited by 283Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Burst activity of ventral tegmental dopamine neurons is elicited by sensory stimuli in the awake cat

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Horvitz, Jon C, Stewart, Tripp, Jacobs, Barry L·1997·Brain Research

DOI 10.1016/s0006-8993(97)00265-5

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Abstract

In light of evidence implicating dopamine in the pathophysiology of attention deficit disorder and schizophrenia, diseases involving attentional or sensory processing abnormalities, it was of interest to determine whether and how dopamine neurons in the ventral tegmental area respond to sensory stimuli. The single-unit responses of ventral tegmental dopamine neurons were recorded in freely-moving cats during the presentation of brief, non-conditioned auditory and visual stimuli. Both auditory and visual stimuli produced neuronal excitation, involving a greater than 5-fold increase in the probability of burst firing followed by a period of burst inhibition. The burst nature of the single-unit response suggests that sensory-induced dopamine release at target sites was disproportionally large relative to the discharge frequency. While characteristics of the dopaminergic sensory response were similar for auditory and visual stimuli, the response latency was longer for visual stimuli. The results demonstrate that dopamine neurons in the ventral tegmental area, the site of origin for mesolimbocortical dopamine neurons, are reliably activated by non-conditioned auditory and visual stimuli.

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Authors: Horvitz, J. C., Stewart, T., & Jacobs, B. L.
Affiliations: Columbia University (US)
Princeton University (US)
Corresponding author: Horvitz, Jon C
ORCID: Horvitz, Jon C
Venue: Brain Research
Publisher: Elsevier BV
Published: 1997-06
Volume: 759
Issue: 2
Pages: 251-258
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(97)00265-5
OpenAlex: W2008177747
Cited by: 283
References: 46
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 16 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 8 · 2013: 15 · 2012: 9
FWCI: 3.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 178 d)
Locations: Brain Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: ventral tegmental area, dopaminergic neurons, burst firing, sensory stimuli, auditory stimuli, visual stimuli, single-unit responses, dopamine release, response latency, attention deficit disorder, schizophrenia, cats
MeSH terms: Acoustic Stimulation, Animals, Cats, Dopamine, Evoked Potentials, Male, Neurons, Photic Stimulation, Tegmentum Mesencephali, Wakefulness

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Burst activity of ventral tegmental dopamine neurons is elicited by sensory stimuli in the awake cat

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