How visual stimuli activate dopaminergic neurons at short latency

Dommett, Eleanor; Coizet, Véronique; Blaha, Charles D.; Martindale, John; Lefebvre, Véronique; Walton, Natalie; Mayhew, John E. W.; Overton, Paul G.; Redgrave, Peter

doi:10.1126/science.1107026

Cited by 285Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

How visual stimuli activate dopaminergic neurons at short latency

Dommett, Eleanor, Coizet, Véronique, Blaha, Charles D., Martindale, John, Lefebvre, Véronique, Walton, Natalie, Mayhew, John E. W., Overton, Paul G. +1 more·2005·Science

DOI 10.1126/science.1107026

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Abstract

Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses.

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It is unclear how NAc dopamine release encodes the properties and/or emotional valence of arousing visual stimuli, such as visual threats.
“While many previous studies have reported phasic firing of dopaminergic neurons in response to light flashes in laboratory animals (Horvitz et al., 1997; Comoli et al., 2003; Dommett et al., 2005), it is unclear how NAc dopamine release encodes the properties and/or emotional valence of arousing visual stimuli, such as visual threats.”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Dommett et al., 2005

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Authors: Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E. W., Overton, P. G., & Redgrave, P.
Affiliations: University of Sheffield (GB)
Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Corresponding author: Dommett, Eleanor
Blaha, Charles D.
Redgrave, Peter
ORCID: Dommett, Eleanor
Blaha, Charles D.
Martindale, John
Overton, Paul G.
Redgrave, Peter
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-03-04
Volume: 307
Issue: 5714
Pages: 1476-1479
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1107026
OpenAlex: W1998893768
Cited by: 285
References: 25
Citations by year: 2026: 6 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 8 · 2019: 16 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 16 · 2013: 23 · 2012: 18
FWCI: 6.51
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopaminergic neurons, superior colliculus, visual stimuli, disinhibition, visual cortex, midbrain, reinforcement learning, salient stimuli
MeSH terms: Animals, Bicuculline, Dopamine, Electrochemistry, Evoked Potentials, Visual, Habituation, Psychophysiologic, Neural Inhibition, Neurons, Photic Stimulation, Reaction Time, Reinforcement, Psychology, Reward, Substantia Nigra, Superior Colliculi, Visual Cortex, Visual Pathways, Neostriatum, Ventral Tegmental Area, Rats

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How visual stimuli activate dopaminergic neurons at short latency

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