Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)
Abstract
We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.
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In the 4-month-old mouse optic nerve, practically all axons are already myelinated.
“We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Bartsch et al., 1997
Myelination in the mouse optic nerve follows a similar course to the rat optic nerve.
“Myelination in the mouse optic nerve follows a similar course (Bartsch et al., 1997; Dangata et al., 1996; Dangata and Kaufman, 1997).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Bartsch et al., 1997
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- Authors
- Bartsch, S., Montag, D., Schachner, M., & Bartsch, U.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Bartsch, Udo
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 762
- Issue
- 1-2
- Pages
- 231-234
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2016745902
- Cited by
- 82
- References
- 17
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- myelin-associated glycoprotein, optic nerve, unmyelinated axons, myelination, retinal ganglion cell axons, axon diameter, CNS myelination
- MeSH terms
- Animals, Microscopy, Electron, Myelin Sheath, Nerve Fibers, Myelinated, Oligodendroglia, Optic Nerve, Mice, Knockout, Myelin-Associated Glycoprotein, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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