Cited by 82Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsNerve injury and regeneration

Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)

Bartsch, Susanne, Montag, Dirk, Schachner, Melitta, Bartsch, Udo·1997·Brain Research

Abstract

We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.

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Crossref · 10.1016/s0006-8993(97)00484-8

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17 of 17 references verified0 citation errors · 0 not checkable

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  • In the 4-month-old mouse optic nerve, practically all axons are already myelinated.

    “We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated.”

    From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Bartsch et al., 1997

  • Myelination in the mouse optic nerve follows a similar course to the rat optic nerve.

    “Myelination in the mouse optic nerve follows a similar course (Bartsch et al., 1997; Dangata et al., 1996; Dangata and Kaufman, 1997).”

    From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Bartsch et al., 1997

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Authors
Bartsch, S., Montag, D., Schachner, M., & Bartsch, U.
Affiliations
ETH Zurich (CH)
Corresponding author
Bartsch, Udo
Venue
Brain Research
Publisher
Elsevier BV
Published
1997-07
Volume
762
Issue
1-2
Pages
231-234
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2016745902
Cited by
82
References
17
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
myelin-associated glycoprotein, optic nerve, unmyelinated axons, myelination, retinal ganglion cell axons, axon diameter, CNS myelination
MeSH terms
Animals, Microscopy, Electron, Myelin Sheath, Nerve Fibers, Myelinated, Oligodendroglia, Optic Nerve, Mice, Knockout, Myelin-Associated Glycoprotein, Mice

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