The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Biophysical aspects of blood flow in the microvasculature
Abstract
The main function of the microvasculature is transport of materials. Water and solutes are carried by blood through the microvessels and exchanged, through vessel walls, with the surrounding tissues. This transport function is highly dependent on the architecture of the microvasculature and on the biophysical behavior of blood flowing through it. For example, the hydrodynamic resistance of a microvascular network, which determines the overall blood flow for a given perfusion pressure, depends on the number, size and arrangement of microvessels, the passive and active mechanisms governing their diameters, and on the apparent viscosity of blood flowing in them. Suspended elements in blood, especially red blood cells, strongly influence the apparent viscosity, which varies with several factors, including vessel diameter, hematocrit and blood flow velocity. The distribution of blood flows and red cell fluxes within a network, which influences the spatial pattern of mass transport, is determined by the mechanics of red cell motion in individual diverging bifurcations. Here, our current understanding of the biophysical processes governing blood flow in the microvasculature is reviewed, and some directions for future research are indicated.
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“The observed profile is flatter than that for laminar flow of a Newtonian fluid in a stiff pipe (Figure 1F), as expected for particle flow in a soft vessel [26].”
From Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion (2006) · cites this paper as [26]
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Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
“RBCs are larger than the capillary diameter in the microcirculation (Pries et al., 1996).”
BackgroundCruz Hernández, J. C., Bracko, O., Kersbergen, C. J., Muse, V., Haft-Javaherian, M., Berg, M., Park, L., Vinarcsik, L. K., Ivasyk, I., Rivera, D. A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0329-4 · Cited by 508
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The Fluid Mechanics of Cancer and Its Therapy
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Metadata
- Authors
- Pries, A. R., Secomb, T. W., & Gaehtgens, P.
- Affiliations
- Freie Universität Berlin (DE)
- University of Arizona (US)
- Corresponding author
- Pries, A.R.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-10-01
- Volume
- 32
- Issue
- 4
- Pages
- 654-667
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2094475932
- Cited by
- 553
- References
- 85
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 16 · 2023: 25 · 2022: 22 · 2021: 25 · 2020: 16 · 2019: 25 · 2018: 32 · 2017: 29 · 2016: 16 · 2015: 37 · 2014: 25 · 2013: 39 · 2012: 22
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (HL34555)
- National Heart, Lung, and Blood Institute (HL 34555)
- Topics
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- microcirculation, blood flow, erythrocytes, hematocrit, mass transfer, solute exchange
- MeSH terms
- Animals, Erythrocyte Deformability, Hematocrit, Humans, Mammals, Microcirculation, Hemorheology
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