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Cited by 553Blood properties and coagulationRheology and Fluid Dynamics StudiesBarrier Structure and Function Studies

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Biophysical aspects of blood flow in the microvasculature

Pries, A.R., Secomb, T.W., Gaehtgens, P.·1996·Cardiovascular Research
DOI 10.1016/s0008-6363(96)00065-x
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Abstract

The main function of the microvasculature is transport of materials. Water and solutes are carried by blood through the microvessels and exchanged, through vessel walls, with the surrounding tissues. This transport function is highly dependent on the architecture of the microvasculature and on the biophysical behavior of blood flowing through it. For example, the hydrodynamic resistance of a microvascular network, which determines the overall blood flow for a given perfusion pressure, depends on the number, size and arrangement of microvessels, the passive and active mechanisms governing their diameters, and on the apparent viscosity of blood flowing in them. Suspended elements in blood, especially red blood cells, strongly influence the apparent viscosity, which varies with several factors, including vessel diameter, hematocrit and blood flow velocity. The distribution of blood flows and red cell fluxes within a network, which influences the spatial pattern of mass transport, is determined by the mechanics of red cell motion in individual diverging bifurcations. Here, our current understanding of the biophysical processes governing blood flow in the microvasculature is reviewed, and some directions for future research are indicated.

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Research works printed but not linked: 12

  1. Skalak R. Rheology of red blood cell membrane. In: Grayson J. Zingg. W. eds. Microcirculation. Vol. 1. New York: Plenum Press. 1976:53-70.
  2. Hochmuth KM, Waugh RE. Erythrocyte membrane elasticity and L iscosity Annu Rev Physiol 1987;49:209-19.
  3. Evans EA, Hochmuth RM Membrane viscoelasticity. Biophys J IY76;16:1-1 I.
  4. Goldsmith HL, Mason SG. Axial migration of particles in Poiseuille tlow. Nature 1961;190: 109.5-6.
  5. Pries AR. Secomh TW. Gaehtgens P, Gross JF. Blood flow in mtcrovascular networks -experiments and simulation. Circ Res lYY0;67:X2h-34.
  6. Martini P, Pierach A, Schreyer E. Die Stromung des Blutes in engen Gefallen. Eine Abweichung vom Poiseuille'schen Geseta. Drsch Arch Klin Med 1930;169:212-22.
  7. Pries AR. Secomb TW, GeSner T, Sperandio MB, Gross JF. Gaehtgens P. Resistance to blood flow in mtcsovessels in viva. Circ Res 1994;75:904-15.
  8. Alonso C. Pries AR. Gaehtgens P. Time-dependent rhenlogical behavtour of blood at low shear in narrow vertical tubes. Am J Physiol iYY3;265:H553-61.
  9. Schmid-Schdnbein H. Fahraeus effect reversal in compaction sta- sis: microrheological and haemodynamic consequences of intravas- cular sedimentation of red cell aggregates. Biorheology 1988;25:355-66.
  10. Fahraeus R. The influence of the rouleaux formation of the erythro- cytes on the rheology of the blood. Acta Med Stand 1958;161:151-65.
  11. Fenton BM, Wilson DW, Cokelet GR. Analysis of the effects of measured white blood cell entrance times on hemodynamics in a [IO11 Kamiya A, Bukhari R, Togawa T. Adaptive regulation of wail computer model of a microvascular bed. Pfliigers Arch Eur J shear stress optimizing vascular tree function. Bull Math Biol Physiol 1985:403:396-401. 1984;6:27-137.
  12. Pries AR, Secomb TW. Gaehtgens P Design principle\ (it vascular heds. Circ Res 1995:77: 1017-1023. Downloaded from https://academic.oup.com/cardiovascres/article/32/4/654/264509 by guest on 07 August 2023

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Metadata

Authors
Pries, A. R., Secomb, T. W., & Gaehtgens, P.
Affiliations
  • Freie Universität Berlin (DE)
  • University of Arizona (US)
Corresponding author
Pries, A.R.
ORCID
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
1996-10-01
Volume
32
Issue
4
Pages
654-667
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/s0008-6363(96)00065-x
OpenAlex
W2094475932
Cited by
553
References
85
Citations by year
2026: 15 · 2025: 33 · 2024: 16 · 2023: 25 · 2022: 22 · 2021: 25 · 2020: 16 · 2019: 25 · 2018: 32 · 2017: 29 · 2016: 16 · 2015: 37 · 2014: 25 · 2013: 39 · 2012: 22
FWCI
4.44
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • National Institutes of Health (HL34555)
  • National Heart, Lung, and Blood Institute (HL 34555)
Topics
  • Health Sciences › Medicine › Hematology › Blood properties and coagulation
  • Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
microcirculation, blood flow, erythrocytes, hematocrit, mass transfer, solute exchange
MeSH terms
Animals, Erythrocyte Deformability, Hematocrit, Humans, Mammals, Microcirculation, Hemorheology

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