The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Estrogen, natriuretic peptides and the renin-angiotensin system.
Abstract
There are significant gender-specific differences in the incidence of hypertension and the clinical outcome of cardiovascular disease between premenopausal women and age-matched men, suggesting that sex hormones such as estrogen (E) might be responsible for the observed cardioprotective effects. This cardioprotective action of E is thought to involve lipoproteins. However, the effect of E on the lipid profile accounts for about 50% of the reduction in cardiovascular disease, indicating that there might be other mechanisms by which E exerts its cardioprotective effects. At present, the underlying mechanism of E action is poorly understood. In this review, the interplay between E, the natriuretic peptides (NP) and the renin-angiotensin system (RAS) is examined. It is hypothesized that E might, through endocrine and/or paracrine action, modulate cardiac NP in females by affecting the RAS either directly or indirectly.
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“Conversely, others have shown that estradiol administration can activate the RAAS by enhancing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and augmenting plasma and tissue levels of renin (15).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [15]
Citations
Cites
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Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701
Sex Differences in Coronary Heart Disease
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Atrial natriuretic peptide: synthesis, release, and metabolism.
Ruskoaho, H. J. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00456-9 · Cited by 547
Estrogen Modulates AT 1 Receptor Gene Expression In Vitro and In Vivo
Nickenig, G., Bäumer, A. T., Grohè, C., Kahlert, S., Strehlow, K., Rosenkranz, S., Stäblein, A., Beckers, F., Smits, J. F. M., Daemen, M. J. A. P., et al. (1998) · Circulation · doi:10.1161/01.cir.97.22.2197 · Cited by 409
Molecular biology of the renin-angiotensin system.
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Cited by
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Impact of age and sex on plasma natriuretic peptide levels in healthy adults
Wang, T. J., Larson, M. G., Levy, D. A., Leip, E. P., Benjamin, E. J., Wilson, P. W. F., Sutherland, P. A., Omland, T., & Vasan, R. S. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02464-5 · Cited by 471
Renin angiotensin system and gender differences in the cardiovascular system
Fischer, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00479-5 · Cited by 384
Clerico, A., & Emdin, M. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.024760 · Cited by 332
Comparative effects of aging in men and women on the properties of the arterial tree
Smulyan, H., Asmar, R. G., Rudnicki, A., London, G. M., & Safar, M. E. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01166-4 · Cited by 307
Clerico, A., Recchia, F. A., Passino, C., & Emdin, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00684.2005 · Cited by 257
Metadata
- Authors
- Kuroski de Bold, M.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 41
- Issue
- 3
- Pages
- 524-531
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2161506816
- Cited by
- 122
- References
- 104
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- estrogen, natriuretic peptides, renin-angiotensin system, sex hormones, hypertension in women, cardiovascular disease, cardioprotection, premenopausal women, lipid profile, paracrine signaling
- MeSH terms
- Animals, Cardiovascular Diseases, Estrogens, Female, Homeostasis, Humans, Hypertension, Male, Middle Aged, Myocardium, Atrial Natriuretic Factor, Receptors, Estrogen, Renin-Angiotensin System, Testosterone, Natriuretic Peptide, Brain, Rats
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