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Role of the aryl hydrocarbon receptor in cell cycle regulation

Puga, Alvaro, Xia, Ying, Elferink, Cornelis·2002·Chemico-Biological Interactions

DOI 10.1016/s0009-2797(02)00069-8

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Abstract

Traditionally, the aryl hydrocarbon receptor (AHR) is considered to be a ligand-activated receptor and transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the combinatorial matrix of cell functions was neatly established long before the first report of an AHR cDNA sequence was published. Only recently, other functions of this protein have begun to be recognized. This review addresses novel findings relating to AHR functions that have resulted from experimental approaches markedly outside traditional receptor analyses. Here we examine the aspects of AHR biology relevant to its role in cell cycle regulation, from the activation of mitogen-activated protein kinases to the cross-talk between AHR and the RAS pathway and the functional significance of the interaction between AHR and the retinoblastoma protein. We have attempted to provide the reader with a balanced interpretation of the evidence, highlighting areas of consensus as well as areas still being contested.

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Authors: Puga, A., Xia, Y., & Elferink, C.
Affiliations: University of Cincinnati Medical Center (US)
The University of Texas Medical Branch at Galveston (US)
Corresponding author: Puga, Alvaro
ORCID: Puga, Alvaro
Xia, Ying
Elferink, Cornelis
Venue: Chemico-Biological Interactions
Publisher: Elsevier BV
Published: 2002-09
Volume: 141
Issue: 1-2
Pages: 117-130
ISSN: 0009-2797 (ISSN-L)
DOI: 10.1016/s0009-2797(02)00069-8
OpenAlex: W2139905874
Cited by: 192
References: 83
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 11
FWCI: 8.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Chemico-Biological Interactions (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (R01ES007800, R01ES010807, ES10807, P30ES006096, R01 ES07800, R01ES006273, P30 ES-06096, R01 ES-06273)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: aryl hydrocarbon receptor, cell cycle regulation, mitogen-activated protein kinase, Ras signaling, retinoblastoma protein, signal transduction, transcription factors, drug-metabolizing enzymes
MeSH terms: Animals, Cell Cycle, Gene Expression Regulation, Phosphorylation, Xenobiotics, Signal Transduction, Oncogene Proteins, Genes, Tumor Suppressor, Receptors, Aryl Hydrocarbon

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Role of the aryl hydrocarbon receptor in cell cycle regulation

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