Cited by 911Toxic Organic Pollutants ImpactImmune Response and InflammationImmunotoxicology and immune responses

The aryl hydrocarbon receptor: multitasking in the immune system

Stockinger, Brigitta, Meglio, Paola Di, Gialitakis, Manolis, Duarte, João H.·2014·Annual Review of Immunology

Abstract

The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists. The evolutionary conservation of this transcription factor and its widespread expression in the immune system point to important physiological functions that are slowly being unraveled. In particular, the emphasis is now shifting from the role of AhR in the xenobiotic pathway toward its mode of action in response to physiological ligands. In this article, we review the current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation, with a focus on barrier organs such as the skin, the gut, and the lung.

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Crossref · 10.1146/annurev-immunol-032713-120245

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164 of 164 references verified0 citation errors · 0 not checkable

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Authors
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H.
Affiliations
National Institute for Medical Research (GB)
Corresponding author
Duarte, João H.
Venue
Annual Review of Immunology
Published
2014-03-21
Volume
32
Issue
1
Pages
403-432
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
OpenAlex
W2112265988
Cited by
909
References
165
Citations by year
2026: 71 · 2025: 66 · 2024: 84 · 2023: 86 · 2022: 87 · 2021: 76 · 2020: 110 · 2019: 78 · 2018: 77 · 2017: 63 · 2016: 55 · 2015: 40 · 2014: 15
FWCI
5.96
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (100910)
  • FP7 Ideas: European Research Council (232782)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
aryl hydrocarbon receptor, immune system, transcription factors, xenobiotic toxicity, 2,3,7,8-tetrachlorodibenzo-p-dioxin, infection, inflammation, skin, intestine, lung
MeSH terms
Animals, Gene Expression Regulation, Humans, Immune System, Ligands, Organ Specificity, Protein Binding, Signal Transduction, Receptors, Aryl Hydrocarbon

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