Comparison of four commercial urinary albumin (microalbumin) methods: implications for detecting diabetic nephropathy using random urine specimens
Abstract
The results of four urinary albumin methods used to identify patients with early diabetic renal disease were compared using random urine samples from healthy and diabetic patients. These methods were the Beckman Array and Behring BNAI immunonephelometric methods, the Dade aca particle-enhanced turbidimetric inhibition immunoassay method, and the INCSTAR SPQ immunoturbidimetric method. The albumin/creatinine ratio reference interval was found to be 2-20 mg albumin/g creatinine (mg/g) for the Array and 3.5-27.5 mg/g for the aca method. All four methods were compared using urines from a group of diabetic and nondiabetic patients. The BNAI, SPQ and Array methods compared well with one another while the aca demonstrated a positive bias of almost 60% at the 30 mg/g and 300 mg/g levels with certain lots of reagent and calibrator. Calibrator cross-over experiments demonstrated that some of the positive bias of the aca method could be accounted for by calibrator differences.
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Most, but not all, methods agree well and support a reference interval of 2-20 mg albumin/mg creatinine.
“Most, but not all, methods agree well and support a reference interval of 2-20 mg albumin/mg creatinine (348).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [348]
Cites
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Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360 · see citing works
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- Authors
- Roberts, W. L., Calcote, C. B., Cook, C. B., Gordon, D. L., Moore, M. L., Moore, S., Scheer, W. D., & Snazelle, B. A.
- Affiliations
- University of Mississippi Medical Center (US)
- Baton Rouge General (US)
- Louisiana State University (US)
- Corresponding author
- Roberts, William L
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 273
- Issue
- 1
- Pages
- 21-33
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W1995034307
- Cited by
- 26
- References
- 11
- Citations by year
- 2024: 2 · 2021: 1 · 2020: 1 · 2013: 2
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- urinary albumin, microalbuminuria, diabetic nephropathy, albumin-creatinine ratio, immunonephelometry, immunoturbidimetric assay, method comparison, reference values
- MeSH terms
- Albuminuria, Creatinine, Diabetic Nephropathies, Humans, Nephelometry and Turbidimetry, Reference Values
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