A comparative study of aluminum(III), gallium(III), indium(III), and thallium(III) binding to human serum transferrin
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About 90% of the aluminium circulating in the blood is transported bound to transferrin, while the rest binds to albumin and citrate.
“About 90% of the Al circulating in the blood is transported bound to transferrin (iron-transporter protein), while the rest of Al binds to albumin and citrate in the blood (Day et al., 1991; Harris and Messori, 2002; Hemadi et al., 2003; Chen et al., 2010).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Harris and Messori, 2002
Cites
Crystal Structure of the Ectodomain of Human Transferrin Receptor
Lawrence, C. M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D. W., & Harrison, S. C. (1999) · Science · doi:10.1126/science.286.5440.779 · Cited by 315 · see citing works
Carrano, C. J., & Raymond, K. N. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00512a047 · Cited by 155 · see citing works
Metal-induced Conformational Changes in Transferrins
Grossmann, J. G., Neu, M., Evans, R. W., Lindley, P. F., Appel, H., & Hasnain, S. S. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1063 · Cited by 67 · see citing works
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998 · see citing works
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395 · see citing works
“About 90% of the Al circulating in the blood is transported bound to transferrin (iron-transporter protein), while the rest of Al binds to albumin and citrate in the blood (Day et al., 1991; Harris and Messori, 2002; Hemadi et al., 2003; Chen et al., 2010).”
Background
- Authors
- Harris, W. R., & Messori, L.
- Affiliations
- University of Missouri–St. Louis (US)
- Corresponding author
- Harris, Wesley R
- Venue
- Coordination Chemistry Reviews
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 228
- Issue
- 2
- Pages
- 237-262
- ISSN
- 0010-8545 (ISSN-L)
- OpenAlex
- W2014064656
- Cited by
- 145
- References
- 3
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coordination Chemistry Reviews (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- group 13 metals, aluminum(III), gallium(III), indium(III), thallium(III), human transferrin, metal ion binding, binding constant, apotransferrin
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