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A Role for the Hippocampus in Card Sorting?
Open accessAbstract
This study examines the performance of three groups of patients with epilepsy on three measures typically used to assess the integrity of the frontal lobes: the Modified Wisconsin Card Sorting Test (MWCST), verbal fluency and the Stroop test. The groups comprised sixteen patients with clearly defined hippocampal sclerosis, thirteen patients with unilateral temporal lobe seizure onset and eighteen patients with unilateral frontal lobe onset. Results demonstrated that performance on the MWCST was most compromised by hippocampal sclerosis. These patients took longer to complete the task, achieved fewer categories and made more perseverative errors than patients in the other groups. In contrast, verbal fluency and performance on the Stroop test were less affected by the presence of hippocampal sclerosis. These results have both clinical and theoretical significance. It is argued that patients with hippocampal damage perform poorly on the MWCST because of the heavy working memory requirements of the test. Cautious use of this test as a tool to localise seizure origin in patients with complex partial seizures is therefore recommended. The findings are discussed in terms of Gray's (1982) model of the hippocampus as a comparator of actions.
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“However this finding has never to our knowledge been entirely replicated, either by Milner or by any other investigator, although there are many failures to replicate (see, e.g., Anderson et al., 1995; Corcoran & Upton, 1993; van den Broek et al., 1993).”
From The case for the development and use of ecologically valid measures of executive function in experimental and clinical neuropsychology (2006) · cites this paper as Corcoran & Upton, 1993
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Metadata
- Authors
- Corcoran, R., & Upton, D.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 29
- Issue
- 2
- Pages
- 293-304
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W2004181597
- Cited by
- 195
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Worcester Research and Publications (University of Worcester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- hippocampus, hippocampal sclerosis, epilepsy, perseverative errors, verbal fluency, Stroop task, working memory, frontal lobe function, temporal lobe epilepsy, frontal lobe epilepsy, complex partial seizures
- MeSH terms
- Adolescent, Adult, Brain Damage, Chronic, Brain Neoplasms, Discrimination Learning, Dominance, Cerebral, Epilepsy, Temporal Lobe, Female, Frontal Lobe, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Neuropsychological Tests, Mental Recall, Temporal Lobe, Epilepsy, Frontal Lobe
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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