The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation
Open accessAbstract
We have undertaken the first detailed analysis of Rho GTPase function during vertebrate development by analyzing how RhoA and Rac1 control convergent extension of axial mesoderm during Xenopus gastrulation. Monitoring of a number of parameters in time-lapse recordings of mesoderm explants revealed that Rac and Rho have both distinct and overlapping roles in regulating the motility of axial mesoderm cells. The cell behaviors revealed by activated or inhibitory versions of these GTPases in native tissue were clearly distinct from those previously documented in cultured fibroblasts. The dynamic properties and polarity of protrusive activity, along with lamellipodia formation, were controlled by the two GTPases operating in a partially redundant manner, while Rho and Rac contributed separately to cell shape and filopodia formation. We propose that Rho and Rac operate in distinct signaling pathways that are integrated to control cell motility during convergent extension.
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“Many other components of non-canonical pathway were also shown to disrupt convergent extension, including Dsh, Fz, Daam1, Rho, Rac, Prickle and Strabismus.65–74”
From Wnt signal transduction pathways (2008) · cites this paper as [70]
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Cites
Normal Table of Xenopus Laevis (Daudin)
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
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Normal table of Xenopus laevis (Daudin)
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Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos
Harland, R. M. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60307-6 · Cited by 2,048
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
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Metadata
- Authors
- Tahinci, E., & Symes, K.
- Affiliations
- Boston University (US)
- Corresponding author
- Symes, Karen
- ORCID
- Symes, Karen
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 259
- Issue
- 2
- Pages
- 318-335
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2090667868
- Cited by
- 162
- References
- 76
- Citations by year
- 2025: 1 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01 CA87375, R01CA087375)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- RhoA, Rac1, convergent extension, Xenopus gastrulation, axial mesoderm, cell motility, lamellipodia, filopodia, cell shape, GTPase signaling
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Embryo, Nonmammalian, Gastrula, Mesoderm, Pseudopodia, Xenopus, Signal Transduction, Cell Polarity, rho GTP-Binding Proteins, rac GTP-Binding Proteins, Cell Size
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