Cited by 162Protein Kinase Regulation and GTPase SignalingDevelopmental Biology and Gene RegulationCellular Mechanics and Interactions

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Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation

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Tahinci, Emilios, Symes, Karen·2003·Developmental Biology

DOI 10.1016/s0012-1606(03)00206-9

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Abstract

We have undertaken the first detailed analysis of Rho GTPase function during vertebrate development by analyzing how RhoA and Rac1 control convergent extension of axial mesoderm during Xenopus gastrulation. Monitoring of a number of parameters in time-lapse recordings of mesoderm explants revealed that Rac and Rho have both distinct and overlapping roles in regulating the motility of axial mesoderm cells. The cell behaviors revealed by activated or inhibitory versions of these GTPases in native tissue were clearly distinct from those previously documented in cultured fibroblasts. The dynamic properties and polarity of protrusive activity, along with lamellipodia formation, were controlled by the two GTPases operating in a partially redundant manner, while Rho and Rac contributed separately to cell shape and filopodia formation. We propose that Rho and Rac operate in distinct signaling pathways that are integrated to control cell motility during convergent extension.

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Authors: Tahinci, E., & Symes, K.
Affiliations: Boston University (US)
Corresponding author: Symes, Karen
ORCID: Symes, Karen
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2003-07
Volume: 259
Issue: 2
Pages: 318-335
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/s0012-1606(03)00206-9
OpenAlex: W2090667868
Cited by: 162
References: 76
Citations by year: 2025: 1 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 8
FWCI: 5.41
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Developmental Biology (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01 CA87375, R01CA087375)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: RhoA, Rac1, convergent extension, Xenopus gastrulation, axial mesoderm, cell motility, lamellipodia, filopodia, cell shape, GTPase signaling
MeSH terms: Animals, Cell Movement, Cells, Cultured, Embryo, Nonmammalian, Gastrula, Mesoderm, Pseudopodia, Xenopus, Signal Transduction, Cell Polarity, rho GTP-Binding Proteins, rac GTP-Binding Proteins, Cell Size

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Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation

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