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Crocidolite-induced lipid peroxidation in rat lung microsomes

Gulumian, Mairam, Kilroe-Smith, Terence Arthur·1987·Environmental Research
DOI 10.1016/s0013-9351(87)80077-4
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Abstract

Lipid peroxidation is increased by ferrous or ferric ions in rat lung microsomes both from rats pretreated with 3-methylcholanthrene and from untreated controls. This increase was dependent on the concentration of these ions in the reaction mixture. Crocidolite alone increased peroxidation in microsomal fractions. However, addition of ferric or ferrous ions with the crocidolite did not give a greater increase in the amount of peroxidation in microsomes. Chelation with EDTA of iron, whether originally present as free ions in the solution or attached to crocidolite, prevented lipid peroxidation. NADPH alone, when added to the microsomal fractions, did not produce any significant effect. However, when added concomitantly with crocidolite fibers, NADPH reduced the effect of crocidolite on lipid peroxidation. Magnesium, manganese, and calcium ions did not produce any significant effect on lipid peroxidation in the presence or absence of crocidolite. A reduced pH enhanced the rate of lipid peroxidation in line with increased solubility of iron salts at these pH values. All the above observations, taken together, lead to the conclusion that it is the iron in the crocidolite that is responsible for the latter's ability to enhance lipid peroxidation.

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Research works printed but not linked: 15

  1. Archakov, 1973, The effect of magnesium ions on the dimethylaniline oxidation rate and electron transfer in liver microsomal fraction, Biochem. J., 136, 371, 10.1042/bj1360371 · DOI
  2. Bagaveev, 1980, Effect of pH on properties of flat bilayer lipid membranes from cholesterol and α-monolaurin, Biofizika, 25, 1091
  3. Blondell, 1980, The anticarcinogenic effect of magnesium, Med. Hypotheses, 6, 863, 10.1016/0306-9877(80)90010-9 · DOI
  4. Brogan, 1981, Factors affecting lipid peroxidation in guinea-pig adrenal microsomes, Biochim. Biophys. Acta, 663, 230, 10.1016/0005-2760(81)90209-5 · DOI
  5. Collins, 1959, 2,4,6-Tripyridyl-s-triazine as a reagent for iron, Anal. Chem., 31, 1862, 10.1021/ac60155a056 · DOI
  6. Currin, 1977, The effect of manganese and ferric ions on the in vitro formation of dihydrodihydroxy metabolites of benzo(a)pyrene, Chem.-Biol. Interact., 19, 259, 10.1016/0009-2797(77)90049-7 · DOI
  7. Diehl, 1960, Iron (II) derivatives of pyridyl-substituted s-triazines, Anal. Chem., 32, 1117, 10.1021/ac60165a020 · DOI
  8. Gulumian, 1983, Lipid peroxidation in microsomes induced by crocidolite fibres, Chem.-Biol. Interact., 44, 111, 10.1016/0009-2797(83)90133-3 · DOI · Paper page
  9. Kornbrust, 1980, Microsomal lipid peroxidation. I. Characterization of the role of iron and NADPH, Mol. Pharmacol., 17, 400
  10. Plaa, 1976, Chemicals, drugs and lipid peroxidation, Annu. Rev. Pharmacol., 16, 125, 10.1146/annurev.pa.16.040176.001013 · DOI
  11. Thomson, 1974, The metabolism of benzo(a)pyrene in rat liver microsomes: The effect of asbestos-associated metal ions and pH, Environ. Res., 7, 149, 10.1016/0013-9351(74)90145-5 · DOI
  12. Thomson, 1978, The effect of asbestos-associated metal ions on the binding of benzo(a)pyrene to macromolecules in vitro, Environ. Res., 15, 309, 10.1016/0013-9351(78)90106-8 · DOI
  13. Topping, 1980, Two-stage carcinogenesis studies with asbestos in Fischer 344 rats, J. Natl. Cancer Inst., 65, 627
  14. Weitzman, 1985, Asbestos-catalysed lipid peroxidation and its inhibition by desferroxamine, Biochem. J., 225, 259, 10.1042/bj2250259 · DOI
  15. Wright, 1980, Lipid peroxidation in guinea pig lung microsomes, Biochim. Biophys. Acta, 619, 374, 10.1016/0005-2760(80)90085-5 · DOI

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Metadata

Authors
Gulumian, M., & Kilroe-Smith, T. A.
Venue
Environmental Research
Publisher
Elsevier BV
Published
1987-06
Volume
43
Issue
1
Pages
267-273
ISSN
0013-9351
DOI
10.1016/s0013-9351(87)80077-4
Cited by
15
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Crocidolite-induced lipid peroxidation in rat lung microsomes. https://app.cochat.ai/papers/10.1016/s0013-9351(87)80077-4
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Gulumian, M., & Kilroe-Smith, T. A. (1987). Crocidolite-induced lipid peroxidation in rat lung microsomes. Environmental Research. https://doi.org/10.1016/s0013-9351(87)80077-4