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Cited by 234Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.

Presynaptic nicotinic receptors modulating dopamine release in the rat striatum

Wonnacott, Susan, Kaiser, Sergio, Mogg, Adrian, Soliakov, Lev, Jones, Ian W·2000·European Journal of Pharmacology
DOI 10.1016/s0014-2999(00)00005-4
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Abstract

The modulation of striatal dopamine release by presynaptic nicotinic acetylcholine receptors is well documented for both synaptosomes and slices. Because the latter retain local anatomical integrity, we have compared [3H]dopamine release evoked by the nicotinic receptor agonists (-)-nicotine and (+/-)-anatoxin-a from striatal synaptosome and slice preparations in parallel. At higher agonist concentrations, mecamylamine-sensitive [3H]dopamine release was greater from slices, indicative of an additional component, and this increase was abolished by glutamate receptor antagonists. To begin to examine the localisation of specific nicotinic acetylcholine receptor subtypes in the striatum, immunogold electron microscopy was undertaken with the beta2-specific monoclonal antibody 270. In striatal sections, gold particles were associated with symmetric synapses (dopaminergic) but were absent from asymmetric synapses (glutamatergic). Surface labelling of striatal synaptosomes with gold particles was also demonstrated. Taken together, these results are consistent with dopamine release mediated by beta2-containing nicotinic acetylcholine receptors on dopamine terminals, while non-beta2-containing nicotinic acetylcholine receptors may enhance dopamine release indirectly by releasing glutamate from neighbouring terminals.

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Crossref · 10.1016/s0014-2999(00)00005-4

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Research works printed but not linked: 2

  1. Grady, 1998, Nicotine stimulated synaptosomal neurotransmitter release from beta-2 null mutant mice, Soc. Neurosci. Abstr., 24, 1342
  2. Kaiser, 1998, Nicotinic receptor modulation of neurotransmitter release, Vol. 8, 141

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Metadata

Authors
Wonnacott, S., Kaiser, S., Mogg, A., Soliakov, L., & Jones, I. W.
Affiliations
University of Bath (GB)
Corresponding author
Wonnacott, Susan
ORCID
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2000-03
Volume
393
Issue
1-3
Pages
51-58
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/s0014-2999(00)00005-4
OpenAlex
W2023915778
Cited by
232
References
36
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 18 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 8
FWCI
4.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Oxford
  • Biotechnology and Biological Sciences Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
presynaptic nicotinic acetylcholine receptors, dopamine release, striatum, anatoxin-a, mecamylamine, synaptosomes, brain slices, glutamate release, glutamate receptor antagonists, dopaminergic terminals, immunogold electron microscopy, nicotinic receptor subtypes
MeSH terms
Animals, Corpus Striatum, Dopamine, Immunohistochemistry, Male, Receptors, Nicotinic, Synaptosomes, Tritium, Rats, Sprague-Dawley, Receptors, Presynaptic, Nicotinic Agonists, Rats, In Vitro Techniques

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