Presynaptic nicotinic ACh receptors

Wonnacott, Susan

doi:10.1016/s0166-2236(96)10073-4

Cited by 1,308Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

Presynaptic nicotinic ACh receptors

Wonnacott, Susan·1997·Trends in Neurosciences

DOI 10.1016/s0166-2236(96)10073-4

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Abstract

Nicotinic ACh (nACh) receptors in the CNS are composed of a diverse array of subunits and have a range of pharmacological properties. However, despite the fact that they are ligand-gated cation channels, their physiological functions have not been determined. This has led to increased interest in presynaptic nACh receptors that act to modulate the release of transmitter from presynaptic terminals.

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Central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons.
“Instead, central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons (Kawai et al., 2007; Rice and Cragg, 2004; Wonnacott, 1997; Zhang and Sulzer, 2004).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Wonnacott, 1997
Stimulation of nicotinic acetylcholine receptors can increase the release of glutamate, GABA, dopamine, acetylcholine, norepinephrine, and serotonin.
“In addition, stimulation of nAChRs can increase the release of glutamate, GABA, dopamine (DA), ACh, norepinephrine, and serotonin (McGehee et al., 1995; Wonnacott, 1997) (Figure 1).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Wonnacott, 1997

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(2004) · Fisheries Research · doi:10.1016/s0165-7836(04)00116-x
Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms
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Presynaptic Nicotinic Receptors in the CNS
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Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions
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Authors: Wonnacott, S.
Affiliations: University of Bath (GB)
Corresponding author: Wonnacott, Susan
ORCID: Wonnacott, Susan
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1997-02
Volume: 20
Issue: 2
Pages: 92-98
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/s0166-2236(96)10073-4
OpenAlex: W2081391428
Cited by: 1,308
References: 74
Citations by year: 2026: 8 · 2025: 8 · 2024: 15 · 2023: 15 · 2022: 31 · 2021: 16 · 2020: 25 · 2019: 17 · 2018: 25 · 2017: 23 · 2016: 26 · 2015: 36 · 2014: 35 · 2013: 37 · 2012: 22
FWCI: 5.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: presynaptic nicotinic acetylcholine receptors, ligand-gated cation channels, neurotransmitter release modulation, presynaptic terminals, receptor pharmacology
MeSH terms: Animals, Brain, Receptors, Nicotinic, Presynaptic Terminals, Rats

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Presynaptic nicotinic ACh receptors

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