Cited by 67Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsPhytoestrogen effects and research

Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats

Berendsen, Hemmie H.G., Weekers, Albert H.J., Kloosterboer, Helenius J.·2001·European Journal of Pharmacology

Abstract

Oestradiol, clonidine, tibolone and raloxifene were tested for their effects on the tail temperature of oestrogen deficient rats, a potential new model that can be used to test compounds that may be of use in the treatment of hot flushes in humans. Rats underwent ovariectomies or sham operations and their tail temperature and physical activity were measured telemetrically. Oestrogen depletion affected tail temperature in the rats' active, but not their resting phase. During the transition from the resting to the active phase, tail temperature in normal rats dropped by about 6 degrees C, but only by approximately 1 degrees C after ovariectomy. Treatment of the ovariectomised rats with oestrogen, clonidine or tibolone dose-dependently restored the drop in tail temperature. However, raloxifene did not change the tail temperature of ovariectomised rats. Thus, tibolone and raloxifene have different effects on the temperature regulation in the tail. This method of measuring tail temperature free of stress in ovariectomised rats may serve as a useful procedure for selecting compounds that are of potential use in the treatment of hot flushes.

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Crossref · 10.1016/s0014-2999(01)00966-9

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Authors
Berendsen, H. H. G., Weekers, A. H. J., & Kloosterboer, H. J.
Affiliations
Organon (Netherlands) (NL)
Corresponding author
Berendsen, Hemmie H.G.
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2001-05
Volume
419
Issue
1
Pages
47-54
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2138633006
Cited by
67
References
43
Citations by year
2025: 2 · 2023: 1 · 2021: 3 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 6 · 2014: 5 · 2013: 4 · 2012: 6
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
Keywords
tibolone, raloxifene, tail temperature, ovariectomy, estrogen deficiency, hot flashes, thermoregulation, clonidine, estradiol, physical activity, telemetry, menopause treatment
MeSH terms
Adrenergic alpha-Agonists, Animals, Body Temperature, Clonidine, Dose-Response Relationship, Drug, Estradiol, Estrogens, Female, Humans, Motor Activity, Norpregnenes, Ovariectomy, Tail, Rats, Wistar, Hot Flashes, Selective Estrogen Receptor Modulators, Raloxifene Hydrochloride, Anabolic Agents, Rats

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