Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats
Abstract
Oestradiol, clonidine, tibolone and raloxifene were tested for their effects on the tail temperature of oestrogen deficient rats, a potential new model that can be used to test compounds that may be of use in the treatment of hot flushes in humans. Rats underwent ovariectomies or sham operations and their tail temperature and physical activity were measured telemetrically. Oestrogen depletion affected tail temperature in the rats' active, but not their resting phase. During the transition from the resting to the active phase, tail temperature in normal rats dropped by about 6 degrees C, but only by approximately 1 degrees C after ovariectomy. Treatment of the ovariectomised rats with oestrogen, clonidine or tibolone dose-dependently restored the drop in tail temperature. However, raloxifene did not change the tail temperature of ovariectomised rats. Thus, tibolone and raloxifene have different effects on the temperature regulation in the tail. This method of measuring tail temperature free of stress in ovariectomised rats may serve as a useful procedure for selecting compounds that are of potential use in the treatment of hot flushes.
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Tail skin temperature is increased by ovariectomy and reduced by estrogen treatment of ovariectomized rats.
“Tail skin temperature is increased by ovariectomy (Berendsen et al., 2001; Kobayashi et al., 1995; Opas et al., 2004) and reduced by estrogen treatment of ovariectomized rats (Berendsen et al., 2001; Bowe et al., 2006; Dacks and Rance, 2010; Hosono et al., 2001; Kobayashi et al., 1995).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Berendsen et al., 2001
Cites
The role of serotonin in hot flushes
Berendsen, H. H. G. (2000) · Maturitas · doi:10.1016/s0378-5122(00)00151-1 · Cited by 235 · see citing works
Self-citationWell-being, symptoms and the menopausal transition
Dennerstein, L. (1996) · Maturitas · doi:10.1016/0378-5122(95)00970-1 · Cited by 220 · see citing works
Sex differences in development of morphine tolerance and dependence in the rat
Craft, R. M., Stratmann, J. A., Bartok, R. E., Walpole, T. I., & King, S. J. (1999) · Psychopharmacology · doi:10.1007/s002130050911 · Cited by 179 · see citing works
Clinical Effects of Raloxifene Hydrochloride in Women
Khovidhunkit, W., & Shoback, D. M. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-5-199903020-00015 · Cited by 165 · see citing works
Kronenberg, F., COTE, L. J., Linkie, D. M., DYRENFURTH, I., & Downey, J. A. (1984) · Maturitas · doi:10.1016/0378-5122(84)90063-x · Cited by 147 · see citing works
Treatment of menopausal hot flashes with transdermal administration of clonidine
Nagamani, M., Kelver, M. E., & Smith, E. R. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90050-0 · Cited by 125 · see citing works
Similarities between morphine withdrawal in the rat and the menopausal hot flush
Simpkins, J. W., Katovich, M. J., & Song, I. C. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90047-4 · Cited by 107 · see citing works
Transdermal Clonidine for Ameliorating Post-Orchiectomy Hot Flashes
Loprinzi, C. L., Goldberg, R. M., O’Fallon, J. R., Quella, S. K., Miser, A. W., Mynderse, L. A., Brown, L. D., Tschetter, L. K., Wilwerding, M. B., Dose, A. M., et al. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)35034-6 · Cited by 91 · see citing works
Tax, L., Goorissen, E. M., & Kicovic, P. M. (1987) · Maturitas · doi:10.1016/0378-5122(87)90038-7 · Cited by 90 · see citing works
Egarter, C., Huber, J., Leikermoser, R., et al. (1996) · Maturitas · doi:10.1016/0378-5122(95)00953-1 · Cited by 85 · see citing works
Clinical experience with tibolone (Livial®) over 8 years
Ginsburg, J., Prelević, G. M., Butler, D., et al. (1995) · Maturitas · doi:10.1016/0378-5122(94)00868-8 · Cited by 81 · see citing works
The effect of estrogens and antiestrogens in a rat model for hot flush
Merchenthaler, I. J., Funkhouser, J. M., Carver, J. M., Lundeen, S. G., Ghosh, K., & Winneker, R. C. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00045-0 · Cited by 75 · see citing works
The effect of transdermal estradiol on hormone and metabolic dynamics over a six-week period.
Haas, S. T., Walsh, B. A., Evans, S., Krache, M., Ravnikar, V. A., & Schiff, I. (1988) · PubMed · Cited by 74 · see citing works
de Visser, J., Coert, A., Feenstra, H., et al. (1984) · PubMed · Cited by 72 · see citing works
A study of the effect of tibolone on the vagina in postmenopausal women
RYMER, J. M., CHAPMAN, M. G., Fogelman, I., et al. (1994) · Maturitas · doi:10.1016/0378-5122(94)90050-7 · Cited by 71 · see citing works
Effect of postmenopausal estrogen therapy on diastolic blood pressure and bodyweight
Utian, W. H. (1978) · Maturitas · doi:10.1016/0378-5122(78)90003-8 · Cited by 67 · see citing works
Effects of clonidine and xylazine on body temperature in the rat
Livingston, A., Low, J., & MORRIS, B. J. (1984) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1984.tb10760.x · Cited by 60 · see citing works
Postmenopausal hot flushes and their management
Lomax, P., & Schönbaum, E. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90060-q · Cited by 60 · see citing works
Reddy, D. S., & Kulkarni, S. K. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01294-6 · Cited by 59 · see citing works
Postmenopausal hormone therapy and breast cancer
Speroff, L. (1996) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00428-9 · Cited by 57 · see citing works
Balfour, J. A. B., & Goa, K. L. (1998) · Drugs & Aging · doi:10.2165/00002512-199812040-00006 · Cited by 57 · see citing works
Tibolone and climacteric symptoms
Ross, L. A., & Alder, E. M. (1995) · Maturitas · doi:10.1016/0378-5122(94)00888-e · Cited by 54 · see citing works
Treatment of hot flushes with mirtazapine: four case reports
Waldinger, M. D., Berendsen, H. H. G., & Schweitzer, D. H. (2000) · Maturitas · doi:10.1016/s0378-5122(00)00152-3 · Cited by 51 · see citing works
Self-citationBlum, A., & Cannon, R. O. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199812000-00010 · Cited by 48 · see citing works
Raloxifene: a selective estrogen receptor modulator.
Scott, J. A., Cc, D. C., & Je, E. (1999) · PubMed · Cited by 46 · see citing works
Effect of intravenous clonidine on menopausal flushing and luteinizing hormone secretion
Tulandi, T., Lal, S., & Kinch, R. A. H. (1983) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1983.tb09327.x · Cited by 44 · see citing works
A double‐blind trial with clonidine and a placebo to treat hot flushes
Wren, B. G., & Brown, L. B. (1986) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1986.tb115924.x · Cited by 44 · see citing works
Effect of chronic estrogen on the skin temperature response to naloxone in morphine-dependent rats
Katovich, M. J., & O'Meara, J. (1987) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y87-095 · Cited by 39 · see citing works
Regional skin temperature changes in a rat model for the menopausal hot flush
Katovich, M. J., Simpkins, J. W., Berglund, L. A., & O'Meara, J. (1986) · Maturitas · doi:10.1016/0378-5122(86)90009-5 · Cited by 39 · see citing works
A Primate Model of Human Postmenopausal Hot Flushes*
Jelínek, J., KAPPEN, A., Schönbaum, E., et al. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1224 · Cited by 37 · see citing works
Endocrine influences on the actions of morphine. I. Alteration of target gland hormones.
Kasson, B. G., & George, R. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33466-x · Cited by 35 · see citing works
Estrogen treatment to ovariectomized rats modifies morphine-induced behavior
Nomikos, G. G., Spyraki, C., Kazandjian, A., et al. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90182-1 · Cited by 30 · see citing works
Temperature Changes Suggestive of Hot Flushes in Rhesus Monkeys: Preliminary Observations
Dierschke, D. J. (1985) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.1985.tb00264.x · Cited by 29 · see citing works
Tejwani, G. A., Sheu, M., Sribanditmongkol, P., & Satyapriya, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00416-8 · Cited by 24 · see citing works
Use of Clonidine to Treat Hot Flashes Secondary to Leuprolide or Goserelin
Bressler, L. R., Murphy, C. M., Shevrin, D. H., et al. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700210 · Cited by 21 · see citing works
Properties of a potent LHRH antagonist (Org 30850) in female and male rats
Deckers, G. H., Graaf, J. H. D., Kloosterboer, H. J., et al. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90111-u · Cited by 18 · see citing works
Self-citationByrd, R. A., & Francis, P. C. (1998) · Reproductive Toxicology · doi:10.1016/s0890-6238(98)00015-x · Cited by 17 · see citing works
Zhang, J., Inazu, M., Tsuji, K., et al. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0468 · Cited by 17 · see citing works
[Results of international clinical trials with raloxifene].
Agnusdei, D., Liu-Léage, S., & Augendre‐Ferrante, B. (1999) · PubMed · Cited by 13 · see citing works
Pathophysiology of Postmenopausal Hot Flushes
Lomax, P. (2015) · Progress in basic and clinical pharmacology · doi:10.1159/000419424 · Cited by 8 · see citing works
Mechanisms Mediating the Thermal Response to Morphine Withdrawal in Rats
Katovich, M. J., Pitman, D. L., & Barney, C. C. (1990) · Experimental Biology and Medicine · doi:10.3181/00379727-193-43013 · Cited by 6 · see citing works
Grossman, L. D. (2000) · Journal SOGC · doi:10.1016/s0849-5831(16)31475-6 · Cited by 5 · see citing works
Mirtazapine in menopausal depression
Tome, M. B., & Isaac, M. (1998) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)80301-5 · Cited by 3 · see citing works
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Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380 · see citing works
Roepke, T. A., Bosch, M. A., Rick, E. A., Lee, B., Wagner, E. J., Seidlova-Wuttke, D., Wuttke, W., Scanlan, T. S., Rønnekleiv, O. K., & Kelly, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0573 · Cited by 103 · see citing works
Williams, H., Dacks, P. A., & Rance, N. E. (2010) · Endocrinology · doi:10.1210/en.2010-0630 · Cited by 44 · see citing works
Walf, A. A., & Frye, C. A. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833a5cb0 · Cited by 34 · see citing works
- Authors
- Berendsen, H. H. G., Weekers, A. H. J., & Kloosterboer, H. J.
- Affiliations
- Organon (Netherlands) (NL)
- Corresponding author
- Berendsen, Hemmie H.G.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 419
- Issue
- 1
- Pages
- 47-54
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2138633006
- Cited by
- 67
- References
- 43
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 3 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 6 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- tibolone, raloxifene, tail temperature, ovariectomy, estrogen deficiency, hot flashes, thermoregulation, clonidine, estradiol, physical activity, telemetry, menopause treatment
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Body Temperature, Clonidine, Dose-Response Relationship, Drug, Estradiol, Estrogens, Female, Humans, Motor Activity, Norpregnenes, Ovariectomy, Tail, Rats, Wistar, Hot Flashes, Selective Estrogen Receptor Modulators, Raloxifene Hydrochloride, Anabolic Agents, Rats
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