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Stimulation of δ1- and δ2-opioid receptors produces amnesia in mice
Abstract
The effects of intracerebroventricular administration of delta1- and delta2-selective opioid receptor agonists on spontaneous alternation performance, elevated plus-maze behavior and passive avoidance learning including step-down and step-through types were examined in mice. Although the delta1-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin (DPLPE) (1-10 microg) or the delta2-selective opioid receptor agonist, [D-Ala2]deltorphin II (deltorphin) (1-10 microg) did not markedly affect spontaneous alternation performance or elevated plus-maze behavior, DPLPE (1, 3 and/or 10 microg) and deltorphin (3 and 10 microg) inhibited passive avoidance learning including step-down and step-through types. The delta1-selective opioid receptor antagonist, 7-benzylidenenaltrexone (3.5 ng), and the delta2-selective opioid receptor antagonist, naltriben (19 ng), significantly antagonized the inhibitory effects of DPLPE (3 microg) and deltorphin (3 microg) on passive avoidance learning, respectively. In contrast, DPLPE (3 microg) or deltorphin (3 microg) did not markedly influence behavioral responses induced by electroshocks during training of passive avoidance learning. Moreover, DPLPE (0.3-3 microg) or deltorphin (0.3-3 microg) failed to significantly affect the radiant heat-induced nociceptive responses. These results suggest that stimulation of delta1- and delta2-opioid receptors produces amnesia, depending on the learning tasks used.
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“Importantly, opioid receptor antagonists appear to reverse the effects of opioid agonists (Ukai et al., 1997;Zhu et al., 2011), and even facilitate memory performance (Canli et al., 1990;Gallagher et al., 1983).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
In the citing paper
“Specifically, treatment with opioid agonists have been reported to interfere with acquisition (Spain and Newsom, 1991;Zhu et al., 2011) and retrieval (Zhu et al., 2011) of spatial memories, and to disrupt working memory (Itoh et al., 1994), avoidance learning (Aguilar et al., 1998;Ukai et al., 1997;Zarrindast and Rezayof, 2004), and spatial recognition memory (Ma et al., 2007).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
In the citing paper
“Opioid receptors are present throughout the cortex and limbic system (Le Merrer et al., 2009) and opioids have been implicated in memory disturbance in the animal literature (Itoh et al., 1994;Ma et al., 2007;Ukai et al., 1997;Zhu et al., 2011).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
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“Importantly, opioid receptor antagonists appear to reverse the effects of opioid agonists (Ukai et al., 1997; Zhu et al., 2011), and even facilitate memory performance (Canli et al., 1990; Gallagher et al., 1983).”
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Metadata
- Authors
- Ukai, M., Takada, A., Sasaki, Y., & Kameyama, T.
- Affiliations
- Meijo University (JP)
- Corresponding author
- Ukai, Makoto
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 338
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2084977336
- Cited by
- 33
- References
- 0
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 2 · 2016: 2 · 2015: 2 · 2013: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- opioid agonists, amnesia, passive avoidance learning, spontaneous alternation, elevated plus maze, deltorphin, 7-benzylidenenaltrexone, naltriben, nociception
- MeSH terms
- Amnesia, Analgesia, Animals, Avoidance Learning, Behavior, Animal, Electroshock, Enkephalins, Male, Oligopeptides, Receptors, Opioid, delta, Enkephalin, D-Penicillamine (2,5)-, Mice
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