The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
Open accessAbstract
Although epidermal growth factor (EGF) induces transient activation of Ras and the mitogen‐activated protein kinase (MAPK) cascade in PC12 cells, whereas nerve growth factor (NGF) stimulates sustained activation, the basis for these contrasting responses is not known. We have developed a computer simulation of EGF‐induced MAPK cascade activation, which provides quantitative evidence that feedback inhibition of the MAPK cascade is the most important factor in determining the duration of cascade activation. Hence, we propose that the observed quantitative differences in EGF and NGF signalling can be accounted for by differential feedback regulation of the MAPK cascade.
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Citations
Cites
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
Kholodenko, B. N. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01197.x · Cited by 643
Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., & Cohen, P. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00059-5 · Cited by 365
Ahmadian, M. R., Hoffmann, U., Goody, R. S., & Wittinghofer, A. (1997) · Biochemistry · doi:10.1021/bi962556y · Cited by 141
Cited by
Cell-signalling dynamics in time and space
Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347
Signalling ballet in space and time
Kholodenko, B. N., Hancock, J. F., & Kolch, W. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2901 · Cited by 614
Negative feedback regulation of the ERK1/2 MAPK pathway
Lake, D., Corrêa, S. A. L., & Müller, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2297-8 · Cited by 565
Mathematical Models of Protein Kinase Signal Transduction
Heinrich, R., Neel, B. G., & Rapoport, T. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00528-2 · Cited by 511
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
Sasagawa, S., Ozaki, Y.-I., Fujita, K., & Kuroda, S. (2005) · Nature Cell Biology · doi:10.1038/ncb1233 · Cited by 451
Metadata
- Authors
- Brightman, F. A., & Fell, D. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-10-05
- Volume
- 482
- Issue
- 3
- Pages
- 169-174
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1990736894
- Cited by
- 247
- References
- 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brightman, F. A., & Fell, D. A. (2000). Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)02037-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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