The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Signalling ballet in space and time
Open accessAbstract
Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries that involve transcriptional feedback. They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions.
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Metadata
- Authors
- Kholodenko, B. N., Hancock, J. F., & Kolch, W.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-06
- Volume
- 11
- Issue
- 6
- Pages
- 414-426
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1968877074
- Cited by
- 614
- References
- 112
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
