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Human monkeypox and smallpox viruses: genomic comparison
Open accessAbstract
Monkeypox virus (MPV) causes a human disease which resembles smallpox but with a lower person‐to‐person transmission rate. To determine the genetic relationship between the orthopoxviruses causing these two diseases, we sequenced the 197‐kb genome of MPV isolated from a patient during a large human monkeypox outbreak in Zaire in 1996. The nucleotide sequence within the central region of the MPV genome, which encodes essential enzymes and structural proteins, was 96.3% identical with that of variola (smallpox) virus (VAR). In contrast, there were considerable differences between MPV and VAR in the regions encoding virulence and host‐range factors near the ends of the genome. Our data indicate that MPV is not the direct ancestor of VAR and is unlikely to naturally acquire all properties of VAR.
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Cited by
Seet, B. T., Johnston, J. B., Brunetti, C. R., Barrett, J. W., Everett, H., Cameron, C., Sypula, J., Nazarian, S. H., Lucas, A., & McFadden, G. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141049 · Cited by 666
The formation and function of extracellular enveloped vaccinia virus
Smith, G. L., Vanderplasschen, A., & Law, M. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-12-2915 · Cited by 559
Poxvirus genomes: a phylogenetic analysis
Gubser, C., Hué, S., Kellam, P., & Smith, G. L. (2004) · Journal of General Virology · doi:10.1099/vir.0.19565-0 · Cited by 406
Monkeypox virus and insights into its immunomodulatory proteins
Weaver, J. R., & Isaacs, S. N. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00691.x · Cited by 295
Smallpox vaccines: targets of protective immunity
Moss, B. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00975.x · Cited by 259
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Metadata
- Authors
- Shchelkunov, S. N., Totmenin, A. V., Babkin, I. V., Safronov, P. F., Ryazankina, O. I., Petrov, N. A., Gutorov, V. V., Uvarova, E. A., Mikheev, M. V., Sisler, J. R., Esposito, J. J., Jahrling, P. B., Moss, B., & Sandakhchiev, L. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2001-11-26
- Volume
- 509
- Issue
- 1
- Pages
- 66-70
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1991404926
- Cited by
- 394
- References
- 0
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shchelkunov, S. N., Totmenin, A. V., Babkin, I. V., Safronov, P. F., Ryazankina, O. I., Petrov, N. A., Gutorov, V. V., Uvarova, E. A., Mikheev, M. V., Sisler, J. R., Esposito, J. J., Jahrling, P. B., Moss, B., & Sandakhchiev, L. S. (2001). Human monkeypox and smallpox viruses: genomic comparison. FEBS Letters. https://doi.org/10.1016/s0014-5793(01)03144-1
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