The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Smallpox vaccines: targets of protective immunity
Open accessAbstract
Summary: The eradication of smallpox, one of the great triumphs of medicine, was accomplished through the prophylactic administration of live vaccinia virus, a comparatively benign relative of variola virus, the causative agent of smallpox. Nevertheless, recent fears that variola virus may be used as a biological weapon together with the present susceptibility of unimmunized populations have spurred the development of new‐generation vaccines that are safer than the original and can be produced by modern methods. Predicting the efficacy of such vaccines in the absence of human smallpox, however, depends on understanding the correlates of protection. This review outlines the biology of poxviruses with particular relevance to vaccine development, describes protein targets of humoral and cellular immunity, compares animal models of orthopoxvirus disease with human smallpox, and considers the status of second‐ and third‐generation smallpox vaccines.
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Cites
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Duration of antiviral immunity after smallpox vaccination
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Cited by
Nonneutralizing Functional Antibodies: a New “Old” Paradigm for HIV Vaccines
Excler, J.-L., Ake, J., Robb, M. L., Kim, J. H., & Plotkin, S. A. (2014) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00230-14 · Cited by 114
Metadata
- Authors
- Moss, B.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-12-28
- Volume
- 239
- Issue
- 1
- Pages
- 8-26
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1905216348
- Cited by
- 259
- References
- 179
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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