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Identification of a Baeyer–Villiger monooxygenase sequence motif
Open accessAbstract
Baeyer–Villiger monooxygenases (BVMOs) form a distinct class of flavoproteins that catalyze the insertion of an oxygen atom in a C–C bond using dioxygen and NAD(P)H. Using newly characterized BVMO sequences, we have uncovered a BVMO‐identifying sequence motif: FXGXXXHXXXW(P/D). Studies with site‐directed mutants of 4‐hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB suggest that this fingerprint sequence is critically involved in catalysis. Further sequence analysis showed that the BVMOs belong to a novel superfamily that comprises three known classes of FAD‐dependent monooxygenases: the so‐called flavin‐containing monooxygenases (FMOs), the N‐hydroxylating monooxygenases (NMOs), and the BVMOs. Interestingly, FMOs contain an almost identical sequence motif when compared to the BVMO sequences: FXGXXXHXXX(Y/F). Using these novel amino acid sequence fingerprints, BVMOs and FMOs can be readily identified in the protein sequence databank.
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Cited by
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van Berkel, W. J. H., Kamerbeek, N. M., & Fraaije, M. W. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.03.044 · Cited by 671
Self-citationKrueger, S. K., & Williams, D. E. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.001 · Cited by 567
Bartsch, M., Gobbato, E., Bednarek, P., Debey, S., Schultze, J. L., Bautor, J., & Parker, J. E. (2006) · The Plant Cell · doi:10.1105/tpc.105.039982 · Cited by 502
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Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468
Baeyer–Villiger Monooxygenases, an Emerging Family of Flavin‐Dependent Biocatalysts
Kamerbeek, N. M., Janssen, D. B., van Berkel, W. J. H., & Fraaije, M. W. (2003) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.200303014 · Cited by 271
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Metadata
- Authors
- Fraaije, M. W., Kamerbeek, N. M., van Berkel, W. J. H., & Janssen, D. B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-04-05
- Volume
- 518
- Issue
- 1-3
- Pages
- 43-47
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2043421474
- Cited by
- 225
- References
- 0
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Fraaije, M. W., Kamerbeek, N. M., van Berkel, W. J. H., & Janssen, D. B. (2002). Identification of a Baeyer–Villiger monooxygenase sequence motif. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)02623-6
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